| Gene Information | |
|---|---|
| Gene Name | CA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 261 |
| Protein Names | Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase B) (CAB) (Carbonic anhydrase I) (CA-I) (Cyanamide hydratase CA1) (EC 4.2.1.69) |
| Target Name | carbonic anhydrase i |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000133742 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P00915 |
| Gene Card | CA1 |
| Uniprot ID | P00915 |
| Pfam | PF00194 |
| In ASD | no |
| Allosteric Prediction | yes (0.694488187) |
| Ortholog in Animals | Alpaca_ CA1 ( ortholog_one2one ) Dog_ CA1 ( ortholog_one2one ) GuineaPig_ CA1 ( ortholog_one2one ) Macaque_ CA1 ( ortholog_one2one ) Mouse_ Car1 ( ortholog_one2one ) Pig_ CA1 ( ortholog_one2one ) Rat_ Car1 ( ortholog_one2one ) |
| Ohnologs | CA7, CA5B, CA5A |
| Paralogs | CA9, CA5B, CA8, CA2, CA12, CA7, CA14, CA3, CA13, CA4, CA5A, CA6, CA11, CA10 |
| Tissue | bone.marrow, colon, rectum, left.ventricle, sigmoid.colon, transverse.colon |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1AZM (X-ray 2.00A ) 1BZM (X-ray 2.00A ) 1CRM (X-ray 2.00A ) 1CZM (X-ray 2.00A ) 1HCB (X-ray 1.60A ) 1HUG (X-ray 2.00A ) 1HUH (X-ray 2.20A ) 1J9W (X-ray 2.60A ) 1JV0 (X-ray 2.00A ) 2CAB (X-ray 2.00A ) 2FOY (X-ray 1.55A ) 2FW4 (X-ray 2.00A ) 2IT4 (X-ray 2.00A ) 2NMX (X-ray 1.55A ) 2NN1 (X-ray 1.65A ) 2NN7 (X-ray 1.85A ) 3LXE (X-ray 1.90A ) 3W6H (X-ray 2.96A ) 3W6I (X-ray 2.69A ) 4WR7 (X-ray 1.50A ) 4WUP (X-ray 1.75A ) 4WUQ (X-ray 1.75A ) 5E2M (X-ray 1.41A ) 5GMM (X-ray 2.00A ) 6EVR (X-ray 1.50A ) 6EX1 (X-ray 1.60A ) 6F3B (X-ray 1.40A ) 6FAF (X-ray 1.99A ) 6FAG (X-ray 1.79A ) 6G3V (X-ray 1.69A ) 6HWZ (X-ray 1.64A ) 6I0J (X-ray 1.35A ) 6I0L (X-ray 1.40A ) 6SWM (X-ray 2.77A ) 6XZE (X-ray 1.54A ) 6XZO (X-ray 1.44A ) 6XZS (X-ray 1.53A ) 6XZX (X-ray 1.55A ) 6XZY (X-ray 1.66A ) 6Y00 (X-ray 1.37A ) 7PLF (X-ray 1.46A ) 7Q0D (X-ray 1.24A ) |
| DBSNP | rs990757234 rs7821248 rs121909577 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:B0BNN3}. |
| Mouse PG classification | NA |
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