Gene Information
Gene NameFHL1
OrganismHomo sapiens (Human)
Gene Length323
Protein NamesFour and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1)
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000022267 )
Evolutionary StageVertebrata
AlphaFoldDBQ13642
Gene CardFHL1
Uniprot IDQ13642
PfamPF00412
In ASDno
Allosteric Predictionno (-0.214900529)
Ortholog in AnimalsMouse_ Fhl4 ( ortholog_one2one )
Rat_ Fhl4 ( ortholog_one2one )
OhnologsFHL2, FHL3
ParalogsLMX1B, LHX1, LHX6, CRIP3, ZFHX4, CRIP1, LHX5, ZFHX3, LMO3, LMO1, LHX4, CRIP2, LHX9, LMO2, LHX8, LMX1A, LHX3, LMO4, ZFHX2, LHX2
TissueNA
Tissue SpecificityIsoform 1 is highly expressed in skeletal muscle and to a lesser extent in heart, placenta, ovary, prostate, testis, small intestine, colon and spleen. Expression is barely detectable in brain, lung, liver, kidney, pancreas, thymus and peripheral blood leukocytes. Isoform 2 is expressed in brain, skeletal muscle and to a lesser extent in heart, colon, prostate and small intestine. Isoform 3 is expressed in testis, heart and skeletal muscle. {ECO:0000269|PubMed:10352231, ECO:0000269|PubMed:10480922, ECO:0000269|PubMed:10524257, ECO:0000269|PubMed:11400158, ECO:0000269|PubMed:9714789}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1X63  (NMR  -  )  2CUP  (NMR  -  )  2CUR  (NMR  -  )  2EGQ  (NMR  -  ) 
DBSNP rs122459147  rs122458140  rs267606812  rs267606813  rs122458142  rs122458143  rs122459146  rs122458144  rs122458145  rs122459149  rs122458141  rs267606811 
Subcellular location [CC][Isoform 1]: Cytoplasm.;
[Isoform 3]: Cytoplasm. Nucleus.;
[Isoform 2]: Nucleus. Cytoplasm, cytosol. Note=Predominantly nuclear in myoblasts but is cytosolic in differentiated myotubes.
Mouse PG classificationNA
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