| Gene Information | |
|---|---|
| Gene Name | KPNA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 538 |
| Protein Names | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000114030 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P52294 |
| Gene Card | KPNA1 |
| Uniprot ID | P52294 |
| Pfam | PF00514; PF16186; PF01749 |
| In ASD | no |
| Allosteric Prediction | yes (0.090356409) |
| Ortholog in Animals | Alpaca_ KPNA1 ( ortholog_one2one ) Dog_ KPNA1 ( ortholog_one2one ) GuineaPig_ KPNA1 ( ortholog_one2one ) Macaque_ KPNA1 ( ortholog_one2one ) Mouse_ Kpna1 ( ortholog_one2one ) Pig_ KPNA1 ( ortholog_one2one ) Rat_ Kpna1 ( ortholog_one2one ) Rabbit_ KPNA1 ( ortholog_one2one ) |
| Ohnologs | KPNA7, KPNA5, KPNA6 |
| Paralogs | KPNA7, KPNA3, KPNA4, KPNA2, KPNA6, KPNA5 |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.010526(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2JDQ (X-ray 2.20A ) 3TJ3 (X-ray 2.70A ) 4B18 (X-ray 2.52A ) 6WX9 (X-ray 2.80A ) |
| DBSNP | rs4678193 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:7604027}. Nucleus {ECO:0000269|PubMed:7604027}. |
| Mouse PG classification | NA |
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