| Gene Information | |
|---|---|
| Gene Name | C9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 559 |
| Protein Names | Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b] |
| Target Name | complement component c9 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000113600 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P02748 |
| Gene Card | C9 |
| Uniprot ID | P02748 |
| Pfam | PF00057; PF01823; PF00090 |
| In ASD | no |
| Allosteric Prediction | yes (0.582098298) |
| Ortholog in Animals | Alpaca_ C9 ( ortholog_one2one ) Dog_ C9 ( ortholog_one2one ) Macaque_ C9 ( ortholog_one2one ) Mouse_ C9 ( ortholog_one2one ) Pig_ C9 ( ortholog_one2one ) Rat_ C9 ( ortholog_one2one ) Rabbit_ C9 ( ortholog_one2one ) |
| Ohnologs | C8B |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, CR1, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | liver |
| Tissue Specificity | Plasma (at protein level). {ECO:0000269|PubMed:22832194, ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:8603752, ECO:0000269|PubMed:9212048, ECO:0000269|PubMed:9634479}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.988529(Rat);0.236091(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5FMW (EM 6.70A ) 6DLW (EM 3.90A ) 6H03 (EM 5.60A ) 6H04 (EM 5.60A ) 7NYC (EM 3.50A ) 7NYD (EM 3.30A ) |
| DBSNP | rs700233 rs121909593 rs696763 rs34882957 rs13361416 rs34625111 rs34421659 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:22832194, ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:8603752, ECO:0000269|PubMed:9212048, ECO:0000269|PubMed:9634479}. Target cell membrane {ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:30111885, ECO:0000269|PubMed:9212048}; Multi-pass membrane protein {ECO:0000269|PubMed:26841934}. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore. {ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:30111885, ECO:0000269|PubMed:4055801, ECO:0000269|PubMed:9634479}. |
| Mouse PG classification | NA |
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