| Gene Information | |
|---|---|
| Gene Name | IMP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 520 |
| Protein Names | Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000177971 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TCT8 |
| Gene Card | SPPL2A |
| Uniprot ID | Q8TCT8 |
| Pfam | PF02225; PF04258 |
| In ASD | no |
| Allosteric Prediction | no (-1.487181653) |
| Ortholog in Animals | Alpaca_ IMP3 ( ortholog_one2one ) Dog_ IMP3 ( ortholog_one2many ) GuineaPig_ IMP3 ( ortholog_one2one ) Macaque_ IMP3 ( ortholog_one2one ) Mouse_ Imp3 ( ortholog_one2one ) Pig_ IMP3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:15385547}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs8034443 |
| Subcellular location [CC] | Late endosome membrane {ECO:0000269|PubMed:16829952}; Multi-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000250|UniProtKB:Q9JJF9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JJF9}. Membrane {ECO:0000269|PubMed:15385547}; Multi-pass membrane protein {ECO:0000305}; Lumenal side {ECO:0000269|PubMed:15385547}. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane. |
| Mouse PG classification | NA |
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