| Gene Information | |
|---|---|
| Gene Name | C8B |
| Organism | Homo sapiens (Human) |
| Gene Length | 591 |
| Protein Names | Complement component C8 beta chain (Complement component 8 subunit beta) |
| Target Name | complement component c8 beta chain |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000021852 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P07358 |
| Gene Card | C8B |
| Uniprot ID | P07358 |
| Pfam | PF00057; PF01823; PF00090 |
| In ASD | no |
| Allosteric Prediction | yes (0.279993054) |
| Ortholog in Animals | Alpaca_ C8B ( ortholog_one2one ) Dog_ C8B ( ortholog_one2one ) GuineaPig_ C8B ( ortholog_one2one ) Macaque_ C8B ( ortholog_one2one ) Mouse_ C8b ( ortholog_one2one ) Pig_ C8B ( ortholog_one2one ) Rat_ C8b ( ortholog_one2one ) Rabbit_ C8B ( ortholog_one2one ) |
| Ohnologs | C6, C7, C9 |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, PRF1, SUSD4, C6, C2 |
| Tissue | liver |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.989243(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3OJY (X-ray 2.51A ) 6H03 (EM 5.60A ) 6H04 (EM 5.60A ) 7NYC (EM 3.50A ) 7NYD (EM 3.30A ) |
| DBSNP | rs12067507 rs1013579 rs12085435 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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