| Gene Information | |
|---|---|
| Gene Name | C8A |
| Organism | Homo sapiens (Human) |
| Gene Length | 584 |
| Protein Names | Complement component C8 alpha chain (Complement component 8 subunit alpha) |
| Target Name | complement component c8 alpha chain |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000157131 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P07357 |
| Gene Card | C8A |
| Uniprot ID | P07357 |
| Pfam | PF00057; PF01823; PF00090 |
| In ASD | no |
| Allosteric Prediction | yes (0.629275852) |
| Ortholog in Animals | Alpaca_ C8A ( ortholog_one2one ) Dog_ C8A ( ortholog_one2one ) GuineaPig_ C8A ( ortholog_one2one ) Macaque_ C8A ( ortholog_one2one ) Mouse_ C8a ( ortholog_one2one ) Pig_ C8A ( ortholog_one2one ) Rat_ C8a ( ortholog_one2one ) Rabbit_ C8A ( ortholog_one2one ) |
| Ohnologs | C6, C7 |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | liver |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.988529(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2QOS (X-ray 1.81A ) 2QQH (X-ray 2.50A ) 2RD7 (X-ray 2.15A ) 3OJY (X-ray 2.51A ) 6H03 (EM 5.60A ) 6H04 (EM 5.60A ) 7NYC (EM 3.50A ) 7NYD (EM 3.30A ) |
| DBSNP | rs652785 rs706479 rs17114555 rs1620075 rs1342440 rs17300936 |
| Subcellular location [CC] | Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells. |
| Mouse PG classification | NA |
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