| Gene Information | |
|---|---|
| Gene Name | C5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1676 |
| Protein Names | Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain] |
| Target Name | c5 messenger rna |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000106804 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P01031 |
| Gene Card | C5 |
| Uniprot ID | P01031 |
| Pfam | PF00207; PF07703; PF07677; PF01821; PF17790; PF01835; PF17791; PF17789; PF01759; PF07678 |
| In ASD | yes |
| Allosteric Prediction | yes (1.202109927) |
| Ortholog in Animals | Alpaca_ C5 ( ortholog_one2one ) Dog_ C5 ( ortholog_one2one ) GuineaPig_ C5 ( ortholog_one2one ) Macaque_ C5 ( ortholog_one2one ) Mouse_ Hc ( ortholog_one2one ) Pig_ C5 ( ortholog_one2one ) Rat_ C5 ( ortholog_one2one ) Rabbit_ C5 ( ortholog_one2one ) |
| Ohnologs | C3 |
| Paralogs | CPAMD8, A2M, C3, A2ML1, CD109, PZP, C4B, C4A |
| Tissue | liver, pancreas |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.987529(Rat);0.234576(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1CFA (NMR - ) 1KJS (NMR - ) 1XWE (NMR - ) 3CU7 (X-ray 3.10A ) 3HQA (X-ray 2.59A ) 3HQB (X-ray 3.30A ) 3KLS (X-ray 3.60A ) 3KM9 (X-ray 4.20A ) 3PRX (X-ray 4.30A ) 3PVM (X-ray 4.30A ) 4A5W (X-ray 3.50A ) 4E0S (X-ray 4.21A ) 4P39 (X-ray 2.40A ) 4UU9 (X-ray 2.12A ) 5B4P (X-ray 2.40A ) 5B71 (X-ray 2.11A ) 5HCC (X-ray 2.59A ) 5HCD (X-ray 2.98A ) 5HCE (X-ray 3.12A ) 5I5K (X-ray 4.20A ) 6H03 (EM 5.60A ) 6H04 (EM 5.60A ) 6RPT (X-ray 2.70A ) 6RQJ (EM 3.50A ) 7AD6 (X-ray 2.75A ) 7AD7 (X-ray 2.30A ) 7NYC (EM 3.50A ) 7NYD (EM 3.30A ) |
| DBSNP | rs17216529 rs34552775 rs2230213 rs17611 rs373359894 rs56040400 rs41309892 rs41309902 rs2230212 rs41311881 rs41311883 rs41311887 rs17609 rs17610 rs16910245 rs17612 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
| click here to return to the previous page | |