| Gene Information | |
|---|---|
| Gene Name | CLIC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 247 |
| Protein Names | Chloride intracellular channel protein 2 (XAP121) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000155962 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15247 |
| Gene Card | CLIC2 |
| Uniprot ID | O15247 |
| Pfam | PF13409 |
| In ASD | no |
| Allosteric Prediction | no (-0.412997056) |
| Ortholog in Animals | Alpaca_ CLIC2 ( ortholog_one2one ) Alpaca_ CLIC2 ( ortholog_one2many ) Dog_ CLIC2 ( ortholog_one2one ) GuineaPig_ CLIC2 ( ortholog_one2one ) Macaque_ CLIC2 ( ortholog_one2one ) Pig_ CLIC2 ( ortholog_one2one ) Rat_ Clic2 ( ortholog_one2one ) Rabbit_ CLIC2 ( ortholog_one2one ) |
| Ohnologs | CLIC6 |
| Paralogs | GSTZ1, GSTO2, GDAP1L1, CLIC3, GSTT4, CLIC4, GSTT2, GSTT2B, CLIC1, EEF1G, GDAP1, GSTO1, CLIC6, CLIC5 |
| Tissue | NA |
| Tissue Specificity | Expressed in adult and fetal brain, heart, skeletal muscle, liver, lung, and spleen. Detected in adult stomach and testis. Expressed in fetal thymus and kidney. {ECO:0000269|PubMed:15147738, ECO:0000269|PubMed:22814392}. |
| Pharmacological Animal Models | 0.025898(Chimpanzee);NULL(Mouse);0.001899(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2PER (X-ray 2.00A ) 2R4V (X-ray 1.85A ) 2R5G (X-ray 1.86A ) |
| DBSNP | rs398122917 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15916532}. Membrane {ECO:0000305|PubMed:15916532}; Single-pass membrane protein {ECO:0000305|PubMed:15916532}. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. |
| Mouse PG classification | NA |
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