| Gene Information | |
|---|---|
| Gene Name | CHCHD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 227 |
| Protein Names | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000106554 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NX63 |
| Gene Card | CHCHD3 |
| Uniprot ID | Q9NX63 |
| Pfam | PF05300 |
| In ASD | no |
| Allosteric Prediction | no (-1.281364147) |
| Ortholog in Animals | Alpaca_ CHCHD3 ( ortholog_one2one ) Dog_ CHCHD3 ( ortholog_one2one ) GuineaPig_ CHCHD3 ( ortholog_one2one ) Macaque_ CHCHD3 ( ortholog_one2one ) Mouse_ Chchd3 ( ortholog_one2one ) Pig_ CHCHD3 ( ortholog_one2one ) Rat_ Chchd3 ( ortholog_one2one ) |
| Ohnologs | CHCHD6 |
| Paralogs | CHCHD6 |
| Tissue | NA |
| Tissue Specificity | Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue. {ECO:0000269|PubMed:22567091}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9CRB9}; Lipid-anchor {ECO:0000305}; Intermembrane side {ECO:0000250|UniProtKB:Q9CRB9}. Cytoplasm {ECO:0000269|PubMed:22567091}. Nucleus {ECO:0000269|PubMed:22567091}. Mitochondrion {ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:25997101}. |
| Mouse PG classification | NA |
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