| Gene Information | |
|---|---|
| Gene Name | C4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1744 |
| Protein Names | Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain] |
| Target Name | complement c4-a |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000206340 ) 3 ( ENSG00000227746 ) 3 ( ENSG00000244207 ) 680 ( ENSG00000244731 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P0C0L4 |
| Gene Card | C4A |
| Uniprot ID | P0C0L4 |
| Pfam | PF00207; PF07703; PF07677; PF01821; PF01835; PF17791; PF17789; PF01759; PF07678 |
| In ASD | no |
| Allosteric Prediction | yes (0.346085775) |
| Ortholog in Animals | Mouse_ C4b ( ortholog_one2many ) Rat_ C4a ( ortholog_many2many ) Rat_ C4b ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | CPAMD8, A2M, C3, A2ML1, CD109, PZP, C5, C4B |
| Tissue | liver, adrenal.gland |
| Tissue Specificity | Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland, and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response. {ECO:0000269|PubMed:11367523}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1HZF (X-ray 2.30A ) 4FXG 4FXK 4XAM 5JPM (X-ray 3.75A ) 5JPN (X-ray 3.60A ) 5JTW (X-ray 3.50A ) 6YSQ (X-ray 3.30A ) |
| DBSNP | rs9296005 rs392610 rs2229405 rs1215093373 rs429329 rs147162052 rs17874654 rs28357075 rs28357076 rs201016130 |
| Subcellular location [CC] | Secreted. Synapse {ECO:0000269|PubMed:26814963}. Cell projection, axon {ECO:0000269|PubMed:26814963}. Cell projection, dendrite {ECO:0000269|PubMed:26814963}. |
| Mouse PG classification | NA |
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