| Gene Information | |
|---|---|
| Gene Name | C3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1663 |
| Protein Names | Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] |
| Target Name | complement c3 |
| Target Type | Clinical trial target |
| Gene Age | 810 ( ENSG00000125730 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P01024 |
| Gene Card | C3 |
| Uniprot ID | P01024 |
| Pfam | PF00207; PF07703; PF07677; PF01821; PF17790; PF01835; PF17791; PF17789; PF01759; PF07678 |
| In ASD | yes |
| Allosteric Prediction | yes (1.53252828) |
| Ortholog in Animals | Alpaca_ C3 ( ortholog_one2one ) Dog_ C3 ( ortholog_one2one ) Macaque_ C3 ( ortholog_one2one ) Mouse_ C3 ( ortholog_one2one ) Pig_ C3 ( ortholog_one2one ) Rat_ C3 ( ortholog_one2one ) |
| Ohnologs | C5 |
| Paralogs | CPAMD8, A2M, A2ML1, CD109, PZP, C5, C4B, C4A |
| Tissue | NA |
| Tissue Specificity | Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods. {ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:9555951}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1C3D (X-ray 1.80A ) 1GHQ (X-ray 2.04A ) 1W2S (X-ray - ) 2A73 (X-ray 3.30A ) 2A74 (X-ray 2.40A ) 2GOX (X-ray 2.20A ) 2I07 (X-ray 4.00A ) 2ICE (X-ray 3.10A ) 2ICF (X-ray 4.10A ) 2NOJ (X-ray 2.70A ) 2QKI (X-ray 2.40A ) 2WII (X-ray 2.70A ) 2WIN (X-ray 3.90A ) 2WY7 (X-ray 1.70A ) 2WY8 (X-ray 1.70A ) 2XQW (X-ray 2.31A ) 2XWB (X-ray 3.49A ) 2XWJ (X-ray 4.00A ) 3D5R (X-ray 2.10A ) 3D5S (X-ray 2.30A ) 3G6J (X-ray 3.10A ) 3L3O (X-ray 3.40A ) 3L5N (X-ray 7.54A ) 3NMS (X-ray 4.10A ) 3OED (X-ray 3.16A ) 3OHX (X-ray 3.50A ) 3OXU (X-ray 2.10A ) 3RJ3 (X-ray 2.35A ) 3T4A (X-ray 3.40A ) 4HW5 (X-ray 2.25A ) 4HWJ (X-ray 2.60A ) 4I6O (X-ray 2.14A ) 4M76 (X-ray 2.80A ) 4ONT (X-ray 2.15A ) 4ZH1 (X-ray 2.24A ) 5FO7 (X-ray 2.80A ) 5FO8 (X-ray 2.40A ) 5FO9 (X-ray 3.30A ) 5FOA (X-ray 4.19A ) 5FOB (X-ray 2.60A ) 5NBQ (X-ray 3.18A ) 5O32 (X-ray 4.21A ) 5O35 (X-ray 4.20A ) 6EHG (X-ray 2.65A ) 6RMT (X-ray 2.00A ) 6RMU (X-ray 2.40A ) 6RUR (X-ray 6.00A ) 6RUV (X-ray 6.15A ) 6S0B (X-ray 2.31A ) 6YO6 (X-ray 6.00A ) 7AKK (X-ray 3.40A ) 7BAG (X-ray 2.00A ) 7NOZ (X-ray 3.90A ) 7PI6 (X-ray 2.60A ) 7QIV (X-ray 2.80A ) 7TV9 (X-ray 3.40A ) 7UE9 (X-ray 1.75A ) |
| DBSNP | rs2230199 rs147859257 rs1047286 rs11569422 rs1449441916 rs121909583 rs771353792 rs117793540 rs11569472 rs121909584 rs121909585 rs11569534 rs11569541 rs7256789 rs1803225 rs2230210 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | HPG |
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