| Gene Information | |
|---|---|
| Gene Name | C22orf18 |
| Organism | Homo sapiens (Human) |
| Gene Length | 180 |
| Protein Names | Centromere protein M (CENP-M) (Interphase centromere complex protein 39) (Proliferation-associated nuclear element protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NSP4 |
| Gene Card | CENPM |
| Uniprot ID | Q9NSP4 |
| Pfam | PF11111 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells. |
| Pharmacological Animal Models | 0.140380(Chimpanzee);0.135300(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4P0T (X-ray 1.49A ) 4WAU (X-ray 2.20A ) 7PKN (EM 3.20A ) 7QOO (EM 4.60A ) 7R5S (EM 2.83A ) 7R5V (EM 4.55A ) 7YWX (EM 12.00A ) 7YYH (EM 8.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres. {ECO:0000250}. |
| Mouse PG classification | NA |
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