| Gene Information | |
|---|---|
| Gene Name | C22orf12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 773 |
| Protein Names | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8WYQ5 |
| Gene Card | DGCR8 |
| Uniprot ID | Q8WYQ5 |
| Pfam | PF00035 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:12705904}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1X47 (NMR - ) 2YT4 (X-ray 2.60A ) 3LE4 (X-ray 1.70A ) 5B16 (X-ray 3.20A ) 6LXD (EM 3.90A ) 6LXE (EM 4.20A ) 6V5B (EM 3.70A ) 6V5C (EM 4.40A ) 7CNC (X-ray 1.60A ) |
| DBSNP | rs35987994 rs11546015 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:22118463}. Nucleus, nucleolus {ECO:0000269|PubMed:17159994}. Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994). |
| Mouse PG classification | NA |
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