| Gene Information | |
|---|---|
| Gene Name | LTA4H |
| Organism | Homo sapiens (Human) |
| Gene Length | 611 |
| Protein Names | Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) |
| Target Name | leukotriene a-4 hydrolase |
| Target Type | Successful target |
| Gene Age | 1488 ( ENSG00000111144 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P09960 |
| Gene Card | LTA4H |
| Uniprot ID | P09960 |
| Pfam | PF09127; PF01433; PF17900 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000382532) |
| Ortholog in Animals | Alpaca_ LTA4H ( ortholog_one2one ) Dog_ LTA4H ( ortholog_one2one ) GuineaPig_ LTA4H ( ortholog_one2one ) Macaque_ LTA4H ( ortholog_one2one ) Mouse_ Lta4h ( ortholog_one2one ) Pig_ LTA4H ( ortholog_one2one ) Rat_ Lta4h ( ortholog_one2one ) Rabbit_ LTA4H ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNPEPL1, NPEPPS, ERAP1, ENPEP, AOPEP, TRHDE, LNPEP, LVRN, ANPEP, RNPEP, ERAP2 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GW6 (X-ray 2.20A ) 1H19 (X-ray 2.10A ) 1HS6 (X-ray 1.95A ) 1SQM (X-ray 2.30A ) 2R59 (X-ray 1.89A ) 2VJ8 (X-ray 1.80A ) 3B7R (X-ray 1.81A ) 3B7S (X-ray 1.47A ) 3B7T (X-ray 2.30A ) 3B7U (X-ray 1.90A ) 3CHO (X-ray 1.80A ) 3CHP (X-ray 2.10A ) 3CHQ (X-ray 2.09A ) 3CHR (X-ray 2.20A ) 3CHS (X-ray 2.55A ) 3FH5 (X-ray 1.63A ) 3FH7 (X-ray 2.05A ) 3FH8 (X-ray 1.67A ) 3FHE (X-ray 2.16A ) 3FTS (X-ray 2.33A ) 3FTU (X-ray 1.90A ) 3FTV (X-ray 1.70A ) 3FTW (X-ray 1.85A ) 3FTX (X-ray 1.96A ) 3FTY (X-ray 2.15A ) 3FTZ (X-ray 2.00A ) 3FU0 (X-ray 1.80A ) 3FU3 (X-ray 2.00A ) 3FU5 (X-ray 2.30A ) 3FU6 (X-ray 2.05A ) 3FUD (X-ray 2.20A ) 3FUE (X-ray 2.38A ) 3FUF (X-ray 2.60A ) 3FUH (X-ray 1.80A ) 3FUI (X-ray 2.20A ) 3FUJ (X-ray 1.90A ) 3FUK (X-ray 1.95A ) 3FUL (X-ray 2.39A ) 3FUM (X-ray 2.15A ) 3FUN (X-ray 1.58A ) 3U9W (X-ray 1.25A ) 4DPR (X-ray 2.02A ) 4L2L (X-ray 1.65A ) 4MKT (X-ray 1.62A ) 4MS6 (X-ray 1.72A ) 4R7L (X-ray 1.66A ) 4RSY (X-ray 1.93A ) 4RVB (X-ray 1.93A ) 5AEN (X-ray 1.86A ) 5BPP (X-ray 2.03A ) 5FWQ (X-ray 2.05A ) 5N3W (X-ray 2.30A ) 5NI2 (X-ray 1.50A ) 5NI4 (X-ray 1.90A ) 5NI6 (X-ray 1.54A ) 5NIA (X-ray 1.76A ) 5NID (X-ray 1.57A ) 5NIE (X-ray 2.60A ) 6ENB (X-ray 1.84A ) 6ENC (X-ray 1.95A ) 6END (X-ray 2.24A ) 6O5H (X-ray 2.84A ) 7AUZ (X-ray 1.90A ) 7AV0 (X-ray 1.90A ) 7AV1 (X-ray 1.79A ) 7AV2 (X-ray 1.95A ) 7KZE (X-ray 2.90A ) 7LLQ (X-ray 2.85A ) |
| DBSNP | rs45630737 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:6490615}. |
| Mouse PG classification | NA |
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