| Gene Information | |
|---|---|
| Gene Name | TNRC6A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1962 |
| Protein Names | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000090905 ) 3 ( ENSG00000288130 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8NDV7 |
| Gene Card | TNRC6A |
| Uniprot ID | Q8NDV7 |
| Pfam | PF10427; PF16608 |
| In ASD | no |
| Allosteric Prediction | yes (0.513591199) |
| Ortholog in Animals | Alpaca_ TNRC6A ( ortholog_one2one ) Dog_ TNRC6A ( ortholog_one2one ) GuineaPig_ TNRC6A ( ortholog_one2one ) Macaque_ TNRC6A ( ortholog_one2one ) Mouse_ Tnrc6a ( ortholog_one2one ) Pig_ TNRC6A ( ortholog_one2one ) Rat_ Tnrc6a ( ortholog_one2one ) Rabbit_ TNRC6A ( ortholog_one2one ) |
| Ohnologs | TNRC6C, TNRC6B |
| Paralogs | UBAC1, UBXN4, TNRC6C, UBXN1, TNRC6B |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:11950943, ECO:0000269|PubMed:29507423}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5W6V (X-ray 2.83A ) 7RUP (X-ray 1.23A ) |
| DBSNP | rs11639856 rs6497759 rs3803716 rs2112782 |
| Subcellular location [CC] | Cytoplasm, P-body {ECO:0000269|PubMed:11950943, ECO:0000269|PubMed:13130130, ECO:0000269|PubMed:15494374, ECO:0000269|PubMed:15908945, ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:18946079, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19324964}. Note=Mammalian P-bodies are also known as GW bodies (GWBs). {ECO:0000305}. |
| Mouse PG classification | NA |
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