Gene Information
Gene NameSETDB2
OrganismHomo sapiens (Human)
Gene Length719
Protein NamesHistone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000136169 )
Evolutionary StageVertebrata
AlphaFoldDBQ96T68
Gene CardSETDB2
Uniprot IDQ96T68
PfamPF01429; PF05033; PF00856
In ASDno
Allosteric Predictionno (-1.331976639)
Ortholog in AnimalsAlpaca_ SETDB2 ( ortholog_one2one )
Dog_ SETDB2 ( ortholog_one2one )
GuineaPig_ SETDB2 ( ortholog_one2one )
Macaque_ SETDB2 ( ortholog_one2one )
Mouse_ Setdb2 ( ortholog_one2one )
Pig_ SETDB2 ( ortholog_one2one )
Rat_ Setdb2 ( ortholog_one2one )
Rabbit_ SETDB2 ( ortholog_one2one )
OhnologsNA
ParalogsKMT2B, ASH1L, NSD3, EHMT2, SUV39H1, EZH1, KMT2A, SETBP1, SETD2, SETD1B, SETD1A, SUV39H2, EHMT1, KMT2D, NSD2, EZH2, KMT2C, NSD1, SETDB1
TissueNA
Tissue SpecificityUbiquitous. Highest expression in heart, testis and ovary.
Pharmacological Animal Models0.070380(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5TFP  (X-ray  2.00A 
DBSNP rs7998427  rs2057413 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:20404330}. Chromosome {ECO:0000305|PubMed:20404330}.
Mouse PG classificationNA
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