| Gene Information | |
|---|---|
| Gene Name | C1RL |
| Organism | Homo sapiens (Human) |
| Gene Length | 487 |
| Protein Names | Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21.-) (C1r-like serine protease analog protein) (CLSPa) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000139178 ) 3 ( ENSG00000288124 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NZP8 |
| Gene Card | C1RL |
| Uniprot ID | Q9NZP8 |
| Pfam | PF00431; PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-0.833862494) |
| Ortholog in Animals | Alpaca_ C1RL ( ortholog_one2one ) Dog_ C1RL ( ortholog_one2one ) GuineaPig_ C1RL ( ortholog_one2one ) Macaque_ C1RL ( ortholog_one2one ) Mouse_ C1rl ( ortholog_one2one ) Pig_ C1RL ( ortholog_one2one ) Rat_ C1rl ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HGFAC, F7, C1R, KLK10, F9, F12, F10, CFI, CFD, PRSS55, PRSS51, C1S, HP, HPR, KLKB1, F11 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level). {ECO:0000269|PubMed:15358180, ECO:0000269|PubMed:15527420}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs3742089 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:15358180}. |
| Mouse PG classification | NA |
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