Gene Information
Gene NameC1R
OrganismHomo sapiens (Human)
Gene Length705
Protein NamesComplement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain]
Target Namecomplement c1r subcomponent
Target TypeNA
Gene Age950 ( ENSG00000159403 )
3 ( ENSG00000288512 )
Evolutionary StageVertebrata
AlphaFoldDBP00736
Gene CardC1R
Uniprot IDP00736
PfamPF00431; PF00084; PF00089
In ASDno
Allosteric Predictionyes (0.297327106)
Ortholog in AnimalsAlpaca_ C1R ( ortholog_one2one )
Dog_ C1R ( ortholog_one2one )
Macaque_ C1R ( ortholog_one2one )
Mouse_ C1ra ( ortholog_one2many )
Mouse_ C1rb ( ortholog_one2many )
Pig_ C1R ( ortholog_one2one )
Rat_ C1r ( ortholog_one2one )
Rabbit_ C1R ( ortholog_one2one )
OhnologsMASP2, MASP1
ParalogsHGFAC, F7, KLK10, F9, F12, F10, CFI, CFD, PRSS55, PRSS51, C1S, C1RL, HP, HPR, KLKB1, F11
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1APQ  (NMR  -  )  1GPZ  (X-ray  2.90A  )  1MD7  (X-ray  3.20A  )  1MD8  (X-ray  2.80A  )  2QY0  (X-ray  2.60A  )  6F1C  (X-ray  4.20A  )  6F1D  (X-ray  1.95A  )  6F1H  (X-ray  4.50A  )  6F39  (X-ray  5.80A  ) 
DBSNP rs1278295523  rs1801046  rs144141261  rs1126605  rs4519167  rs3813728  rs1057518643  rs1057519026  rs1057515579  rs760277934  rs1057519576  rs769707492  rs1057519577  rs1057518645  rs1057519578  rs1057519579  rs1060499554 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:27745832}.
Mouse PG classificationNA
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