| Gene Information | |
|---|---|
| Gene Name | MOV10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1003 |
| Protein Names | Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000155363 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9HCE1 |
| Gene Card | MOV10 |
| Uniprot ID | Q9HCE1 |
| Pfam | PF13087 |
| In ASD | no |
| Allosteric Prediction | yes (0.341271253) |
| Ortholog in Animals | Alpaca_ MOV10 ( ortholog_one2one ) Dog_ MOV10 ( ortholog_one2one ) GuineaPig_ MOV10 ( ortholog_one2one ) Macaque_ MOV10 ( ortholog_one2one ) Mouse_ Mov10 ( ortholog_one2one ) Pig_ MOV10 ( ortholog_one2one ) Rat_ Mov10 ( ortholog_one2one ) Rabbit_ MOV10 ( ortholog_one2one ) |
| Ohnologs | MOV10L1 |
| Paralogs | SETX, AQR, UPF1, DNA2, IGHMBP2, HELZ, ZNFX1, HELZ2, MOV10L1, CT55 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, P-body {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30122351}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:30122351}. Cytoplasm, Stress granule {ECO:0000269|PubMed:23093941}. Nucleus {ECO:0000250|UniProtKB:P23249}. Cytoplasm {ECO:0000250|UniProtKB:P23249}. Note=Co-enriched in cytoplasmic foci with TUT4 (PubMed:30122351). In developing neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (By similarity). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30122351}. |
| Mouse PG classification | NA |
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