| Gene Information | |
|---|---|
| Gene Name | C10orf99 |
| Organism | Homo sapiens (Human) |
| Gene Length | 81 |
| Protein Names | Protein GPR15LG (Antimicrobial peptide with 57 amino acid residues) (AP-57) (Antimicrobial peptide-57) (Colon-derived SUSD2 binding factor) (CSBF) (Protein GPR15 ligand) (Protein GPR15L) (Secreted protein C10orf99) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q6UWK7 |
| Gene Card | C10orf99 |
| Uniprot ID | Q6UWK7 |
| Pfam | PF15854 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | Alpaca_ C10H10orf99 ( ortholog_one2one ) Dog_ C10orf99 ( ortholog_one2one ) Mouse_ 2610528A11Rik ( ortholog_one2one ) Pig_ GPRL15 ( ortholog_one2one ) Rabbit_ C10orf99 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in colon, and cervix and at moderate level in tonsil (PubMed:25585381, PubMed:28900043). Highly reduced expression in primary colon cancer tissues compared with that in adjacent tissues (PubMed:25351403). Highest levels of expression detected in stomach and colon; expressed in epithelium of skin and esophagus, and in some tumor and/or tumor adjacent tissues (TAT), including TAT of esophagus cancer, hepatocellular carcinoma (HCC), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and invasive ductal carcinoma (IDC) tissues (at protein level) (PubMed:25585381). Highly expressed by inflammatory differentiated keratinocytese (PubMed:35704588). {ECO:0000269|PubMed:25585381, ECO:0000269|PubMed:28900043, ECO:0000269|PubMed:35704588}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:25351403, ECO:0000269|PubMed:25585381}. |
| Mouse PG classification | NA |
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