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Gene Information
Gene Name
BCHE
Organism
Homo sapiens (Human)
Gene Length
602
Protein Names
Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)
Target Name
cholinesterase
Target Type
NA
Gene Age
382 ( ENSG00000114200 )
Evolutionary Stage
Opisthokonta
AlphaFoldDB
P06276
Gene Card
BCHE
Uniprot ID
P06276
Pfam
PF08674; PF00135
In ASD
yes
Allosteric Prediction
yes (1.435756132)
Ortholog in Animals
Alpaca_ BCHE ( ortholog_one2one )
Dog_ BCHE ( ortholog_one2one )
GuineaPig_ BCHE ( ortholog_one2one )
Macaque_ BCHE ( ortholog_one2one )
Mouse_ Bche ( ortholog_one2one )
Rat_ Bche ( ortholog_one2one )
Rabbit_ BCHE ( ortholog_one2one )
Ohnologs
ACHE
Paralogs
NLGN2, ACHE, NLGN4X, NLGN4Y, CES3, NLGN1, CES2, CES5A, CES4A, TG, NLGN3, CES1, CEL
Tissue
NA
Tissue Specificity
Detected in blood plasma (at protein level). Present in most cells except erythrocytes. {ECO:0000269|PubMed:19368529, ECO:0000269|PubMed:19542320}.
Pharmacological Animal Models
NA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1P0I
(X-ray
2.00A
)
1P0M
(X-ray
2.38A
)
1P0P
(X-ray
2.30A
)
1P0Q
(X-ray
2.43A
)
1XLU
(X-ray
2.20A
)
1XLV
(X-ray
2.25A
)
1XLW
(X-ray
2.10A
)
2J4C
(X-ray
2.75A
)
2PM8
(X-ray
2.80A
)
2WID
(X-ray
2.30A
)
2WIF
(X-ray
2.25A
)
2WIG
(X-ray
2.15A
)
2WIJ
(X-ray
2.10A
)
2WIK
(X-ray
2.10A
)
2WIL
(X-ray
3.10A
)
2WSL
(X-ray
2.00A
)
2XMB
(X-ray
2.10A
)
2XMC
(X-ray
2.40A
)
2XMD
(X-ray
2.30A
)
2XMG
(X-ray
2.70A
)
2XQF
(X-ray
2.10A
)
2XQG
(X-ray
2.30A
)
2XQI
(X-ray
2.60A
)
2XQJ
(X-ray
2.40A
)
2XQK
(X-ray
2.40A
)
2Y1K
(X-ray
2.50A
)
3DJY
(X-ray
2.10A
)
3DKK
(X-ray
2.31A
)
3O9M
(X-ray
2.98A
)
4AQD
(X-ray
2.50A
)
4AXB
(X-ray
2.40A
)
4B0O
(X-ray
2.35A
)
4B0P
(X-ray
2.50A
)
4BBZ
(X-ray
2.70A
)
4BDS
(X-ray
2.10A
)
4TPK
(X-ray
2.70A
)
4XII
(X-ray
2.70A
)
5DYT
(X-ray
2.55A
)
5DYW
(X-ray
2.50A
)
5DYY
(X-ray
2.65A
)
5K5E
(X-ray
2.80A
)
5LKR
(X-ray
2.52A
)
5NN0
(X-ray
2.10A
)
6EMI
(X-ray
2.48A
)
6EP4
(X-ray
2.30A
)
6EQP
(X-ray
2.35A
)
6EQQ
(X-ray
2.40A
)
6ESJ
(X-ray
2.98A
)
6ESY
(X-ray
2.80A
)
6EUL
6EYF
(X-ray
2.60A
)
6EZ2
(X-ray
2.70A
)
6F7Q
(X-ray
2.60A
)
6I0B
(X-ray
2.38A
)
6I0C
(X-ray
2.67A
)
6I2T
(EM
5.70A
)
6QAA
(X-ray
1.90A
)
6QAB
(X-ray
2.49A
)
6QAC
(X-ray
2.77A
)
6QAD
(X-ray
2.50A
)
6QAE
(X-ray
2.49A
)
6R6V
(X-ray
2.50A
)
6R6W
(X-ray
2.47A
)
6RUA
(X-ray
2.75A
)
6SAM
(X-ray
2.50A
)
6T9P
(X-ray
2.70A
)
6T9S
(X-ray
2.70A
)
6XTA
(X-ray
2.50A
)
6ZWI
(X-ray
1.85A
)
7AIY
(X-ray
2.94A
)
7AMZ
(X-ray
2.25A
)
7AWG
(X-ray
2.00A
)
7AWH
(X-ray
2.30A
)
7AWI
(X-ray
2.30A
)
7BGC
(X-ray
2.40A
)
7BO3
(X-ray
2.20A
)
7BO4
(X-ray
2.40A
)
DBSNP
rs116047990
rs56309853
rs531738678
rs116097205
rs1553778274
rs148170012
rs1799807
rs979653503
rs1339128583
rs755600722
rs3732880
rs201820739
rs747598704
rs121918558
rs527843566
rs781368801
rs370077923
rs28933389
rs892642457
rs16849700
rs115624085
rs754644618
rs104893684
rs770337031
rs121918557
rs115129687
rs745364489
rs28933390
rs200998515
rs115017300
rs769316835
rs121918556
rs199660374
rs1803274
Subcellular location [CC]
Secreted {ECO:0000269|PubMed:19368529, ECO:0000269|PubMed:19542320}.
Mouse PG classification
NA
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