| Gene Information | |
|---|---|
| Gene Name | BUBR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1050 |
| Protein Names | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O60566 |
| Gene Card | BUB1B |
| Uniprot ID | O60566 |
| Pfam | PF08311 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index. {ECO:0000269|PubMed:10593653}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.260390(Mouse);0.358394(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2WVI (X-ray 1.80A ) 3SI5 (X-ray 2.20A ) 4GGD (X-ray 2.44A ) 5JJA (X-ray 2.35A ) 5K6S (X-ray 2.79A ) 5KHU (EM 4.80A ) 5LCW (EM 4.00A ) 5SWF (X-ray 2.82A ) 6TLJ (EM 3.80A ) |
| DBSNP | rs1392369693 rs534297115 rs56079734 rs1801376 rs17851677 rs1017842 rs28989187 rs1801528 rs28989182 rs28989181 rs28989184 rs28989183 rs28989185 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and KNL1. |
| Mouse PG classification | NA |
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