| Gene Information | |
|---|---|
| Gene Name | BUB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1085 |
| Protein Names | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) |
| Target Name | bub1 mitotic checkpoint serine/threonine kinase |
| Target Type | Patented-recorded target |
| Gene Age | 1488 ( ENSG00000169679 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43683 |
| Gene Card | BUB1 |
| Uniprot ID | O43683 |
| Pfam | PF08311; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.115552611) |
| Ortholog in Animals | Alpaca_ BUB1 ( ortholog_one2one ) Dog_ BUB1 ( ortholog_one2one ) GuineaPig_ BUB1 ( ortholog_one2one ) Macaque_ BUB1 ( ortholog_one2one ) Mouse_ Bub1 ( ortholog_one2one ) Pig_ BUB1 ( ortholog_one2one ) Rat_ Bub1 ( ortholog_one2one ) Rabbit_ BUB1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BUB1B |
| Tissue | appendix, testis, brain |
| Tissue Specificity | High expression in testis and thymus, less in colon, spleen, lung and small intestine. Expressed in fetal thymus, bone marrow, heart, liver, spleen and thymus. Expression is associated with cells/tissues with a high mitotic index. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2LAH (NMR - ) 4A1G (X-ray 2.60A ) 4QPM (X-ray 2.20A ) 4R8Q (X-ray 2.31A ) 5DMZ (X-ray 2.40A ) 6F7B (X-ray 2.00A ) 7B1F (X-ray 1.75A ) 7B1H (X-ray 2.40A ) 7B1J (X-ray 2.90A ) |
| DBSNP | rs35890336 rs1801328 rs121909055 rs36109304 rs376649190 |
| Subcellular location [CC] | Nucleus. Chromosome, centromere, kinetochore. Note=Nuclear in interphase cells. Accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase. AURKB, KNL1 and INCENP are required for kinetochore localization (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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