| Gene Information | |
|---|---|
| Gene Name | BTRC |
| Organism | Homo sapiens (Human) |
| Gene Length | 605 |
| Protein Names | F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000166167 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y297 |
| Gene Card | BTRC |
| Uniprot ID | Q9Y297 |
| Pfam | PF12125; PF12937; PF00400 |
| In ASD | no |
| Allosteric Prediction | yes (0.10150548) |
| Ortholog in Animals | Alpaca_ BTRC ( ortholog_one2one ) Dog_ BTRC ( ortholog_one2one ) GuineaPig_ BTRC ( ortholog_one2one ) Macaque_ BTRC ( ortholog_one2one ) Mouse_ Btrc ( ortholog_one2one ) Pig_ BTRC ( ortholog_one2one ) Rat_ Btrc ( ortholog_one2one ) Rabbit_ BTRC ( ortholog_one2one ) |
| Ohnologs | FBXW11 |
| Paralogs | FBXW12, FBXW11, WDR49, FBXO36, FBXW8, PAAF1, WDR64, EFCAB8, WDR86, FBXO16, TRAF7, FBXW9, FBXW7, WDR54 |
| Tissue | NA |
| Tissue Specificity | Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.011588(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1P22 (X-ray 2.95A ) 2P64 (X-ray 2.50A ) 6M90 (X-ray 2.05A ) 6M91 (X-ray 2.40A ) 6M92 (X-ray 2.35A ) 6M93 (X-ray 2.50A ) 6M94 (X-ray 2.70A ) 6TTU (EM 3.70A ) |
| DBSNP | rs4151060 rs2270439 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q3ULA2}. Nucleus {ECO:0000250|UniProtKB:Q3ULA2}. |
| Mouse PG classification | NA |
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