| Gene Information | |
|---|---|
| Gene Name | BTKI |
| Organism | Homo sapiens (Human) |
| Gene Length | 1353 |
| Protein Names | Inhibitor of Bruton tyrosine kinase (IBtk) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9P2D0 |
| Gene Card | IBTK |
| Uniprot ID | Q9P2D0 |
| Pfam | PF12796; PF00651; PF00415 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues. {ECO:0000269|PubMed:11577348, ECO:0000269|PubMed:18596081}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12662902 rs9449444 |
| Subcellular location [CC] | Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation.; [Isoform 2]: Nucleus. |
| Mouse PG classification | NA |
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