| Gene Information | |
|---|---|
| Gene Name | BTC |
| Organism | Homo sapiens (Human) |
| Gene Length | 178 |
| Protein Names | Probetacellulin [Cleaved into: Betacellulin (BTC)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000174808 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P35070 |
| Gene Card | BTC |
| Uniprot ID | P35070 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.300421086) |
| Ortholog in Animals | Alpaca_ BTC ( ortholog_one2one ) Dog_ BTC ( ortholog_one2one ) GuineaPig_ BTC ( ortholog_one2one ) Macaque_ BTC ( ortholog_one2one ) Mouse_ Btc ( ortholog_one2one ) Pig_ BTC ( ortholog_one2one ) Rat_ Btc ( ortholog_one2one ) Rabbit_ BTC ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EREG, AREG, EPGN, TGFA, HBEGF |
| Tissue | NA |
| Tissue Specificity | Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine. {ECO:0000269|PubMed:8919026}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IOX (NMR - ) 1IP0 (NMR - ) |
| DBSNP | rs28549760 rs56320257 rs11938093 |
| Subcellular location [CC] | [Betacellulin]: Secreted, extracellular space.; [Probetacellulin]: Cell membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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