| Gene Information | |
|---|---|
| Gene Name | KIAA1961 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1166 |
| Protein Names | Folliculin-interacting protein 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8TF40 |
| Gene Card | FNIP1 |
| Uniprot ID | Q8TF40 |
| Pfam | PF14638; PF14637; PF14636 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue. Expressed in peripheral blood mononuclear cells (PubMed:32181500). {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:32181500}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7730228 rs13177318 rs26008 rs12109782 rs7717874 |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:29848618}. Cytoplasm, cytosol {ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:29848618}. Note=Localizes to lysosome membrane in amino acid-depleted conditions and relocalizes to the cytosol upon refeeding (PubMed:29848618). Colocalizes with FLCN in the cytoplasm (PubMed:18663353). {ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:29848618}. |
| Mouse PG classification | NA |
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