| Gene Information | |
|---|---|
| Gene Name | BST2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 180 |
| Protein Names | Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000130303 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q10589 |
| Gene Card | BST2 |
| Uniprot ID | Q10589 |
| Pfam | PF16716 |
| In ASD | no |
| Allosteric Prediction | no (-0.759396753) |
| Ortholog in Animals | Alpaca_ BST2 ( ortholog_one2one ) Macaque_ BST2 ( ortholog_one2one ) Mouse_ Bst2 ( ortholog_one2one ) Rat_ Bst2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level). {ECO:0000269|PubMed:10329429, ECO:0000269|PubMed:16157322}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2LK9 (NMR - ) 2X7A (X-ray 2.77A ) 2XG7 (X-ray 3.45A ) 3MQ7 (X-ray 2.28A ) 3MQ9 (X-ray 2.80A ) 3MQB (X-ray 3.20A ) 3MQC (X-ray 2.80A ) 3NWH (X-ray 2.60A ) 4P6Z (X-ray 3.00A ) 6CM9 (EM 3.73A ) 6CRI (EM 6.80A ) 6D83 (EM 4.27A ) 6D84 (EM 6.72A ) 6DFF (EM 3.90A ) |
| DBSNP | rs1804402 |
| Subcellular location [CC] | Golgi apparatus, trans-Golgi network. Cell membrane {ECO:0000269|PubMed:26172439}; Single-pass type II membrane protein. Cell membrane {ECO:0000269|PubMed:19879838, ECO:0000269|PubMed:26172439}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19879838, ECO:0000305|PubMed:26172439}. Membrane raft. Cytoplasm. Apical cell membrane {ECO:0000250}. Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. Forms a complex with MMP14 and localizes to the cytoplasm.; Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:26172439}. Late endosome {ECO:0000269|PubMed:20419159}. Note=(Microbial infection) HIV-1 VPU and HIV-2 ENV can target it to the trans-Golgi network thus sequestering it away from virus assembly sites on the cell membrane. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. {ECO:0000269|PubMed:20419159, ECO:0000269|PubMed:26172439}. |
| Mouse PG classification | NA |
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