Gene Information
Gene NameSLC9B2
OrganismHomo sapiens (Human)
Gene Length537
Protein NamesSodium/hydrogen exchanger 9B2 (Na(+)/H(+) exchanger NHA2) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Sodium/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000164038 )
Evolutionary StageCellular_organisms
AlphaFoldDBQ86UD5
Gene CardSLC9B2
Uniprot IDQ86UD5
PfamPF00999
In ASDno
Allosteric Predictionno (-1.205878096)
Ortholog in AnimalsAlpaca_ SLC9B2 ( ortholog_one2one )
Dog_ SLC9B2 ( ortholog_one2one )
GuineaPig_ SLC9B2 ( ortholog_one2one )
Macaque_ SLC9B2 ( ortholog_one2one )
Mouse_ Slc9b2 ( ortholog_one2one )
Pig_ SLC9B2 ( ortholog_one2one )
Rabbit_ SLC9B2 ( ortholog_one2one )
OhnologsNA
ParalogsSLC9B1
TissueNA
Tissue SpecificityWidely expressed (PubMed:18508966). High levels detected in the distal tubules of the kidney nephron (PubMed:18508966). Detected in red blood cells (at protein level) (PubMed:18000046, PubMed:18508966). {ECO:0000269|PubMed:18000046, ECO:0000269|PubMed:18508966}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7B4L  (EM  3.10A  )  7B4M  (EM  7.20A  ) 
DBSNP rs7672710  rs7672707  rs2276976 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:18000046};
Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:18508966};
Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q5BKR2};
Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q5BKR2};
Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5BKR2}. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q5BKR2};
Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q5BKR2};
Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q5BKR2};
Multi-pass membrane protein {ECO:0000255}. Note=Strong colocalization with LAMP1 and TCIRG1 in osteoclasts. In beta-cells colocalizes with RAB4A and SYP. Localizes to the basolateral membrane of polarized osteoclasts. {ECO:0000250|UniProtKB:Q5BKR2}.
Mouse PG classificationNA
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