Gene Information
Gene NameBSG
OrganismHomo sapiens (Human)
Gene Length385
Protein NamesBasigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)
Target Namebasigin
Target TypeClinical trial target
Gene Age950 ( ENSG00000172270 )
Evolutionary StageEumetazoa
AlphaFoldDBP35613
Gene CardBSG
Uniprot IDP35613
PfamNA
In ASDno
Allosteric Predictionno (-0.219971454)
Ortholog in AnimalsAlpaca_ BSG ( ortholog_one2one )
Dog_ BSG ( ortholog_one2one )
GuineaPig_ BSG ( ortholog_one2one )
Macaque_ BSG ( ortholog_one2one )
Mouse_ Bsg ( ortholog_one2one )
Rat_ Bsg ( ortholog_one2one )
OhnologsNPTN
ParalogsEMB, NPTN, VSTM2L
TissueNA
Tissue Specificity[Isoform 1]: Retina-specific (PubMed:25957687). Expressed in retinal cone photoreceptors (at protein level) (PubMed:25957687). {ECO:0000269|PubMed:25957687}.;
[Isoform 2]: Expressed in erythrocytes (at protein level) (PubMed:26195724, PubMed:28409866). Highly expressed in melanoma cell lines (at protein level) (PubMed:11992541). Highly expressed in the heart, kidney, skeletal muscle and testis (PubMed:21536654). {ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:21536654, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.;
[Isoform 3]: Highly expressed in the bone marrow, fetal liver, lung, testis and thymus. {ECO:0000269|PubMed:21536654}.;
[Isoform 4]: Highly expressed in the bone marrow, fetal liver, lung, testis and thymus. {ECO:0000269|PubMed:21536654}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3B5H  (X-ray  2.80A  )  3I84  (X-ray  2.00A  )  3I85  (X-ray  2.50A  )  3QQN  (X-ray  2.31A  )  3QR2  (X-ray  2.30A  )  4U0Q  (X-ray  3.10A  )  5X0T  (X-ray  2.50A  )  5XF0  (NMR  -  )  6LYY  (EM  3.60A  )  6LZ0  (EM  3.60A  )  7CKO  (EM  2.95A  )  7CKR  (EM  3.00A  )  7DA5  (EM  3.30A  )  7DAA  (X-ray  2.51A  )  7DCE  (EM  3.80A  ) 
DBSNP rs201850688  rs11551906  rs144824657  rs14704  rs2229662  rs55911144  rs104894669  rs1803203 
Subcellular location [CC]Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.;
[Isoform 1]: Cell membrane {ECO:0000269|PubMed:25957687};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P18572}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P18572}.;
[Isoform 2]: Cell membrane {ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:15688292, ECO:0000269|PubMed:15946952, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:21536654, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866, ECO:0000269|PubMed:29739904};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Endosome {ECO:0000269|PubMed:29739904}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15688292};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Basolateral cell membrane {ECO:0000269|PubMed:17267690};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.;
[Isoform 3]: Cell membrane {ECO:0000269|PubMed:21536654};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.;
[Isoform 4]: Cell membrane {ECO:0000269|PubMed:21536654};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.
Mouse PG classificationNA
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