| Gene Information | |
|---|---|
| Gene Name | SYNJ2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1496 |
| Protein Names | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000078269 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15056 |
| Gene Card | SYNJ2 |
| Uniprot ID | O15056 |
| Pfam | PF08952; PF03372; PF02383 |
| In ASD | no |
| Allosteric Prediction | no (-0.246231543) |
| Ortholog in Animals | Alpaca_ SYNJ2 ( ortholog_one2one ) Dog_ SYNJ2 ( ortholog_one2one ) GuineaPig_ SYNJ2 ( ortholog_one2one ) Macaque_ SYNJ2 ( ortholog_one2one ) Mouse_ Synj2 ( ortholog_one2one ) Pig_ SYNJ2 ( ortholog_one2one ) Rat_ Synj2 ( ortholog_one2one ) Rabbit_ SYNJ2 ( ortholog_one2one ) |
| Ohnologs | SYNJ1 |
| Paralogs | SH2D1B, SH2D1A, FIG4, INPP5E, SACM1L, OCRL, INPP5D, INPPL1, INPP5F, INPP5J, SYNJ1, INPP5B, INPP5K |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.016667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1UFW (NMR - ) |
| DBSNP | rs2502601 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11084340}. Cell membrane {ECO:0000269|PubMed:11084340}. Membrane raft {ECO:0000269|PubMed:11084340}. Presynapse {ECO:0000250|UniProtKB:O55207}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O55207}. Note=Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340). {ECO:0000269|PubMed:11084340}. |
| Mouse PG classification | NA |
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