Gene Information
Gene NameBRSK1
OrganismHomo sapiens (Human)
Gene Length778
Protein NamesSerine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1)
Target Namebr serine/threonine kinase 1
Target TypeLiterature-reported target
Gene Age424 ( ENSG00000160469 )
Evolutionary StageEukaryota
AlphaFoldDBQ8TDC3
Gene CardBRSK1
Uniprot IDQ8TDC3
PfamPF00069
In ASDno
Allosteric Predictionno (-0.646995556)
Ortholog in AnimalsAlpaca_ BRSK1 ( ortholog_one2one )
Dog_ BRSK1 ( ortholog_one2one )
GuineaPig_ BRSK1 ( ortholog_one2one )
Macaque_ BRSK1 ( ortholog_one2one )
Mouse_ Brsk1 ( ortholog_one2one )
Pig_ BRSK1 ( ortholog_one2one )
Rat_ Brsk1 ( ortholog_one2one )
Rabbit_ BRSK1 ( ortholog_one2one )
OhnologsNA
ParalogsTSSK6, SNRK, SIK2, SIK3, NIM1K, NUAK2, TSSK2, TSSK4, SIK1, PRKAA2, BRSK2, NUAK1, HUNK, PRKAA1, TSSK1B, MELK, TSSK3
Tissuecerebral.cortex, brain
Tissue SpecificityWidely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle. {ECO:0000269|PubMed:15150265}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs144130246  rs55892637  rs12978445  rs55796422 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:15150265}. Nucleus {ECO:0000269|PubMed:15150265}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Synapse {ECO:0000250|UniProtKB:B2DD29}. Presynaptic active zone {ECO:0000250|UniProtKB:B2DD29}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:B2DD29}. Note=Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity). {ECO:0000250}.
Mouse PG classificationNA
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