Gene Information | |
---|---|
Gene Name | BRSK1 |
Organism | Homo sapiens (Human) |
Gene Length | 778 |
Protein Names | Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1) |
Target Name | br serine/threonine kinase 1 |
Target Type | Literature-reported target |
Gene Age | 424 ( ENSG00000160469 ) |
Evolutionary Stage | Eukaryota |
AlphaFoldDB | Q8TDC3 |
Gene Card | BRSK1 |
Uniprot ID | Q8TDC3 |
Pfam | PF00069 |
In ASD | no |
Allosteric Prediction | no (-0.646995556) |
Ortholog in Animals | Alpaca_ BRSK1 ( ortholog_one2one ) Dog_ BRSK1 ( ortholog_one2one ) GuineaPig_ BRSK1 ( ortholog_one2one ) Macaque_ BRSK1 ( ortholog_one2one ) Mouse_ Brsk1 ( ortholog_one2one ) Pig_ BRSK1 ( ortholog_one2one ) Rat_ Brsk1 ( ortholog_one2one ) Rabbit_ BRSK1 ( ortholog_one2one ) |
Ohnologs | NA |
Paralogs | TSSK6, SNRK, SIK2, SIK3, NIM1K, NUAK2, TSSK2, TSSK4, SIK1, PRKAA2, BRSK2, NUAK1, HUNK, PRKAA1, TSSK1B, MELK, TSSK3 |
Tissue | cerebral.cortex, brain |
Tissue Specificity | Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle. {ECO:0000269|PubMed:15150265}. |
Pharmacological Animal Models | NA |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | NA |
DBSNP | rs144130246 rs55892637 rs12978445 rs55796422 |
Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15150265}. Nucleus {ECO:0000269|PubMed:15150265}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Synapse {ECO:0000250|UniProtKB:B2DD29}. Presynaptic active zone {ECO:0000250|UniProtKB:B2DD29}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:B2DD29}. Note=Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity). {ECO:0000250}. |
Mouse PG classification | NA |
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