| Gene Information | |
|---|---|
| Gene Name | BRPF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1214 |
| Protein Names | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000156983 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P55201 |
| Gene Card | BRPF1 |
| Uniprot ID | P55201 |
| Pfam | PF00439; PF10513; PF00855 |
| In ASD | no |
| Allosteric Prediction | no (-0.237120735) |
| Ortholog in Animals | Alpaca_ BRPF1 ( ortholog_one2one ) Dog_ BRPF1 ( ortholog_one2one ) GuineaPig_ BRPF1 ( ortholog_one2one ) Macaque_ BRPF1 ( ortholog_one2one ) Mouse_ Brpf1 ( ortholog_one2one ) Pig_ BRPF1 ( ortholog_one2one ) Rat_ Brpf1 ( ortholog_one2one ) Rabbit_ BRPF1 ( ortholog_one2one ) |
| Ohnologs | BRPF3, BRD1 |
| Paralogs | MLLT10, JADE3, JADE2, BRPF3, PHF14, MLLT6, BRD1, JADE1 |
| Tissue | NA |
| Tissue Specificity | High levels in testis. {ECO:0000269|PubMed:7906940}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2D9E (NMR - ) 2RS9 (NMR - ) 2X35 (X-ray 2.00A ) 2X4W (X-ray 1.50A ) 2X4X (X-ray 1.85A ) 2X4Y (X-ray 1.70A ) 3L42 (X-ray 1.30A ) 3MO8 (X-ray 1.69A ) 4LC2 (X-ray 1.65A ) 4QYD (X-ray 1.94A ) 4QYL (X-ray 1.80A ) 4UYE (X-ray 1.65A ) 5C6S (X-ray 1.30A ) 5C7N (X-ray 1.75A ) 5C85 (X-ray 1.70A ) 5C87 (X-ray 1.55A ) 5C89 (X-ray 1.65A ) 5D7X (X-ray 1.35A ) 5DY7 (X-ray 1.69A ) 5DYA (X-ray 1.65A ) 5DYC (X-ray 1.65A ) 5E3D (X-ray 1.71A ) 5E3G (X-ray 1.65A ) 5EM3 (X-ray 1.40A ) 5EPR (X-ray 1.65A ) 5EPS (X-ray 1.47A ) 5EQ1 (X-ray 1.55A ) 5ERC (X-ray 2.05A ) 5ETB (X-ray 1.33A ) 5ETD (X-ray 1.40A ) 5EV9 (X-ray 1.45A ) 5EVA (X-ray 1.45A ) 5EWC (X-ray 1.75A ) 5EWD (X-ray 1.58A ) 5EWH (X-ray 1.63A ) 5EWV (X-ray 1.67A ) 5EWW (X-ray 1.73A ) 5FFV (X-ray 1.30A ) 5FFW (X-ray 1.50A ) 5FFY (X-ray 1.55A ) 5FG4 (X-ray 1.65A ) 5FG5 (X-ray 1.50A ) 5G4R (X-ray 1.96A ) 5G4S (X-ray 1.60A ) 5MWG (X-ray 1.50A ) 5MWH (X-ray 1.65A ) 5MWZ (X-ray 1.25A ) 5MYG (X-ray 2.30A ) 5O4S (X-ray 1.75A ) 5O4T (X-ray 1.50A ) 5O55 (X-ray 1.45A ) 5O5A (X-ray 1.60A ) 5O5F (X-ray 1.30A ) 5O5H (X-ray 1.85A ) 5OV8 (X-ray 1.80A ) 5OWA (X-ray 1.95A ) 5OWB (X-ray 1.65A ) 5OWE (X-ray 1.70A ) 5T4U (X-ray 1.50A ) 5T4V (X-ray 1.65A ) 6EKQ (X-ray 1.65A ) 6U04 (X-ray 2.20A ) 7C4I (X-ray 1.37A ) |
| DBSNP | rs1057519509 rs1057519515 rs1042294 rs36081837 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. Chromosome {ECO:0000269|PubMed:24065767}. Cytoplasm {ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:27939640}. Note=Localization to the nucleus depends on KAT6A, ING5 and MEAF6 (PubMed:18794358, PubMed:27939640). Localizes to transcription start sites (PubMed:24065767). {ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| Mouse PG classification | NA |
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