| Gene Information | |
|---|---|
| Gene Name | ABCB5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1257 |
| Protein Names | ATP-binding cassette sub-family B member 5 (ABCB5 P-gp) (P-glycoprotein ABCB5) (EC 7.6.2.2) |
| Target Name | atp-binding cassette sub-family b member 5 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000004846 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q2M3G0 |
| Gene Card | ABCB5 |
| Uniprot ID | Q2M3G0 |
| Pfam | PF00664; PF00005 |
| In ASD | no |
| Allosteric Prediction | yes (0.238496168) |
| Ortholog in Animals | Alpaca_ ABCB5 ( ortholog_one2one ) Dog_ ABCB5 ( ortholog_one2one ) GuineaPig_ ABCB5 ( ortholog_one2one ) Macaque_ ABCB5 ( ortholog_one2one ) Mouse_ Abcb5 ( ortholog_one2one ) Pig_ ABCB5 ( ortholog_one2one ) Rat_ Abcb5 ( ortholog_one2one ) Rabbit_ ABCB5 ( ortholog_one2one ) |
| Ohnologs | ABCB11 |
| Paralogs | ABCB6, TAP1, ABCB11, ABCB4, ABCB9, ABCB8, TAP2, ABCB7, ABCB1, ABCB10 |
| Tissue | NA |
| Tissue Specificity | Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium. {ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15760339, ECO:0000269|PubMed:22044138, ECO:0000269|PubMed:22675422, ECO:0000269|PubMed:22784549, ECO:0000269|PubMed:23770371, ECO:0000269|PubMed:24934811, ECO:0000269|PubMed:25030174}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2301641 rs13222448 rs1187237313 rs35885925 rs17143304 rs6461515 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12960149}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12960149}. |
| Mouse PG classification | NA |
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