Gene Information
Gene NameSGSM1
OrganismHomo sapiens (Human)
Gene Length1148
Protein NamesSmall G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000167037 )
Evolutionary StageEumetazoa
AlphaFoldDBQ2NKQ1
Gene CardSGSM1
Uniprot IDQ2NKQ1
PfamPF12068; PF00566; PF02759
In ASDno
Allosteric Predictionno (-1.213426877)
Ortholog in AnimalsAlpaca_ SGSM1 ( ortholog_one2many )
Dog_ SGSM1 ( ortholog_one2one )
GuineaPig_ SGSM1 ( ortholog_one2one )
Macaque_ SGSM1 ( ortholog_one2one )
Mouse_ Sgsm1 ( ortholog_one2one )
Pig_ SGSM1 ( ortholog_one2one )
Rat_ Sgsm1 ( ortholog_one2one )
Rabbit_ SGSM1 ( ortholog_one2one )
OhnologsSGSM2
ParalogsTBC1D3C, TBC1D3D, TBC1D3, TBC1D3G, TBC1D3B, TBC1D3F, TBC1D3I, TBC1D3E, TBC1D3L, TBC1D3H, TBC1D3K, TBC1D8, TBC1D14, TBC1D10A, TBC1D8B, TBC1D2B, TBC1D10B, RABGAP1, TBC1D17, TBC1D9B, TBC1D25, TBC1D30, TBC1D26, TBC1D28, TBC1D22A, USP6NL, TBC1D9, RABGAP1L, TBC1D2, TBC1D13, TBC1D12, SGSM2, TBC1D4, GRTP1, EVI5, EVI5L, TBC1D15, SGSM3, TBC1D16, TBCK, TBC1D22B, TBC1D5, TBC1D1, TBC1D10C, TBC1D21
TissueNA
Tissue SpecificityMainly expressed in brain, heart and testis. {ECO:0000269|PubMed:17509819}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs6004350  rs2073201 
Subcellular location [CC]Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8BPQ7}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:22637480};
Peripheral membrane protein {ECO:0000269|PubMed:22637480}. Cytoplasm {ECO:0000269|PubMed:22637480}. Note=Recruited to cytoplasmic vesicle membranes via its interaction with Rab family members, such as RAB9A. {ECO:0000269|PubMed:22637480}.
Mouse PG classificationNA
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