| Gene Information | |
|---|---|
| Gene Name | DSG4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1040 |
| Protein Names | Desmoglein-4 (Cadherin family member 13) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000175065 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q86SJ6 |
| Gene Card | DSG4 |
| Uniprot ID | Q86SJ6 |
| Pfam | PF01049; PF00028 |
| In ASD | no |
| Allosteric Prediction | no (-1.207723107) |
| Ortholog in Animals | Alpaca_ DSG4 ( ortholog_one2one ) Dog_ DSG4 ( ortholog_one2one ) GuineaPig_ DSG4 ( ortholog_one2one ) Macaque_ DSG4 ( ortholog_one2one ) Mouse_ Dsg4 ( ortholog_one2one ) Pig_ DSG4 ( ortholog_one2one ) Rabbit_ DSG4 ( ortholog_one2one ) |
| Ohnologs | CDH3, CDH15, CDH13 |
| Paralogs | DSG1, DSG3, DSG2, DSC2, DSC1, DSC3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in skin, testis and prostate; less in salivary gland. In scalp follicles, present in the inner root sheath (IRS) and all layers of the matrix and precortex. {ECO:0000269|PubMed:12648213, ECO:0000269|PubMed:12705872}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs13381457 rs7229252 rs4799570 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, desmosome {ECO:0000250}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |