Gene Information
Gene NameBRI
OrganismHomo sapiens (Human)
Gene Length266
Protein NamesIntegral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ9Y287
Gene CardITM2B
Uniprot IDQ9Y287
PfamPF04089
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityUbiquitous. Expressed in brain.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs11556905  rs606231283 
Subcellular location [CC][Integral membrane protein 2B]: Golgi apparatus membrane {ECO:0000269|PubMed:14656991, ECO:0000269|PubMed:19114711};
Single-pass type II membrane protein {ECO:0000269|PubMed:10526337}. Note=Immature BRI2 (imBRI2) is cleaved by furin in the Golgi into mBRI2 and a Bri23 peptide. mBRI2 is transported to the plasma membrane and Bri23 peptide is secreted.;
[BRI2, membrane form]: Cell membrane {ECO:0000269|PubMed:18440095, ECO:0000269|PubMed:19748705, ECO:0000269|PubMed:21752865};
Single-pass type II membrane protein {ECO:0000269|PubMed:10526337}. Endosome membrane {ECO:0000269|PubMed:19748705};
Single-pass type II membrane protein {ECO:0000269|PubMed:10526337}. Note=Mature BRI2 (mBRI2) needs to be transported from the endoplasmic reticulum compartment to the cell membrane in order to be able to inhibit APP processing. {ECO:0000269|PubMed:19748705}.;
[Bri23 peptide]: Secreted {ECO:0000269|PubMed:10526337, ECO:0000269|PubMed:14656991, ECO:0000269|PubMed:18524908}. Note=Detected in the cerebral spinal fluid (CSF). {ECO:0000269|PubMed:18524908}.;
[BRI2C, soluble form]: Secreted {ECO:0000269|PubMed:17965014}.
Mouse PG classificationNA
click here to return to the previous page