| Gene Information | |
|---|---|
| Gene Name | BRG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1647 |
| Protein Names | Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P51532 |
| Gene Card | SMARCA4 |
| Uniprot ID | P51532 |
| Pfam | PF07533; PF00439; PF00271; PF07529; PF08880; PF14619; PF00176 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). {ECO:0000269|PubMed:20418909}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.609034(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2GRC (X-ray 1.50A ) 2H60 (NMR - ) 3UVD (X-ray 1.85A ) 5DKD (X-ray 2.00A ) 5EA1 (X-ray 2.00A ) 6BGH (NMR - ) 6HR2 (X-ray 1.76A ) 6LTH (EM 3.00A ) 6LTJ (EM 3.70A ) 6SY2 (NMR - ) 6ZS2 (X-ray 1.57A ) 7VDT (EM 2.80A ) 7VDV (EM 3.40A ) |
| DBSNP | rs1804579 rs281875226 rs281875227 rs281875228 rs281875229 rs1801514 rs281875230 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549, ECO:0000269|PubMed:20418909}. Note=Colocalizes with long non-coding RNA Evf2 in nuclear RNA clouds. {ECO:0000250|UniProtKB:Q3TKT4}. |
| Mouse PG classification | NA |
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