| Gene Information | |
|---|---|
| Gene Name | BRDT |
| Organism | Homo sapiens (Human) |
| Gene Length | 947 |
| Protein Names | Bromodomain testis-specific protein (Cancer/testis antigen 9) (CT9) (RING3-like protein) |
| Target Name | bromodomain testis-specific protein |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000137948 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q58F21 |
| Gene Card | BRDT |
| Uniprot ID | Q58F21 |
| Pfam | PF17035; PF17105; PF00439 |
| In ASD | no |
| Allosteric Prediction | no (-0.7868657) |
| Ortholog in Animals | Alpaca_ BRDT ( ortholog_one2one ) Dog_ BRDT ( ortholog_one2one ) Macaque_ BRDT ( ortholog_one2one ) Mouse_ Brdt ( ortholog_one2one ) Pig_ BRDT ( ortholog_one2one ) Rat_ Brdt ( ortholog_one2one ) Rabbit_ BRDT ( ortholog_one2one ) |
| Ohnologs | BRD4, BRD3, BRD2 |
| Paralogs | BRD4, BAZ1A, KAT2A, CECR2, BAZ2A, BAZ1B, BRD3, BRD2, BAZ2B, KAT2B, BPTF |
| Tissue | testis |
| Tissue Specificity | Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder. {ECO:0000269|PubMed:10704737, ECO:0000269|PubMed:15647849, ECO:0000269|PubMed:9367677}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2RFJ (X-ray 2.05A ) 4FLP (X-ray 2.23A ) 4KCX (X-ray 2.00A ) 5VBQ (X-ray 1.65A ) 5VBR (X-ray 1.90A ) 7BJY (X-ray 2.22A ) 7L73 (X-ray 1.46A ) 7L99 (X-ray 1.90A ) 7L9A (X-ray 2.27A ) 7LEJ (X-ray 1.73A ) 7LEK (X-ray 2.75A ) 7LEL (X-ray 2.15A ) 7LEM (X-ray 1.89A ) 7MRC (X-ray 1.55A ) 7MRD (X-ray 1.39A ) 7MRG (X-ray 1.99A ) 7MRH (X-ray 1.98A ) 7UBO (X-ray 1.82A ) 7UUU (X-ray 1.52A ) 8CZA (X-ray 2.96A ) |
| DBSNP | rs55806733 rs56273490 rs10783071 rs781375003 rs1156281 rs1064567 rs34674879 rs3088232 rs55912588 rs35327986 rs10747493 rs754258809 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20538714, ECO:0000269|PubMed:22901802, ECO:0000269|PubMed:22971749}. Note=Detected on chromatin. {ECO:0000250|UniProtKB:Q91Y44}. |
| Mouse PG classification | NA |
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