| Gene Information | |
|---|---|
| Gene Name | CYP8B1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 501 |
| Protein Names | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (EC 1.14.14.139) (7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase) (CYPVIIIB1) (Cytochrome P450 8B1) (Sterol 12-alpha-hydroxylase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000180432 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9UNU6 |
| Gene Card | CYP8B1 |
| Uniprot ID | Q9UNU6 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | no (-0.504891583) |
| Ortholog in Animals | Alpaca_ CYP8B1 ( ortholog_one2one ) Dog_ CYP8B1 ( ortholog_one2one ) Macaque_ CYP8B1 ( ortholog_one2one ) Mouse_ Cyp8b1 ( ortholog_one2one ) Pig_ CYP8B1 ( ortholog_one2one ) Rat_ Cyp8b1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PTGIS |
| Tissue | liver |
| Tissue Specificity | Liver. {ECO:0000269|PubMed:10051404}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7LYX (X-ray 2.60A ) |
| DBSNP | rs9865715 rs199955644 rs35764459 rs35637877 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O02766}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:O02766}; Single-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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