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Gene Information
Gene Name
BRD2
Organism
Homo sapiens (Human)
Gene Length
801
Protein Names
Bromodomain-containing protein 2 (O27.1.1) (Really interesting new gene 3 protein)
Target Name
bromodomain-containing protein 2
Target Type
Clinical trial target
Gene Age
886 ( ENSG00000204256 )
3 ( ENSG00000215077 )
3 ( ENSG00000230678 )
3 ( ENSG00000234507 )
3 ( ENSG00000234704 )
3 ( ENSG00000235307 )
3 ( ENSG00000236227 )
Evolutionary Stage
Eukaryota
AlphaFoldDB
P25440
Gene Card
BRD2
Uniprot ID
P25440
Pfam
PF17035; PF00439
In ASD
no
Allosteric Prediction
no (-0.070606759)
Ortholog in Animals
Alpaca_ BRD2 ( ortholog_one2one )
Dog_ BRD2 ( ortholog_one2one )
GuineaPig_ BRD2 ( ortholog_one2one )
Macaque_ BRD2 ( ortholog_one2one )
Mouse_ Brd2 ( ortholog_one2one )
Pig_ BRD2 ( ortholog_one2one )
Rat_ Brd2 ( ortholog_one2one )
Rabbit_ BRD2 ( ortholog_one2one )
Ohnologs
BRDT
Paralogs
BRD3, BAZ1A, BRD4, BRDT, KAT2A, CECR2, BAZ2A, BAZ1B, BAZ2B, KAT2B, BPTF
Tissue
NA
Tissue Specificity
NA
Pharmacological Animal Models
NA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1X0J
(X-ray
1.80A
)
2DVQ
(X-ray
2.04A
)
2DVR
(X-ray
2.30A
)
2DVS
(X-ray
2.04A
)
2DVV
(X-ray
1.80A
)
2E3K
(X-ray
2.30A
)
2G4A
(NMR
-
)
2YDW
(X-ray
1.90A
)
2YEK
(X-ray
1.98A
)
3AQA
(X-ray
2.30A
)
3ONI
(X-ray
1.61A
)
4A9E
(X-ray
1.91A
)
4A9F
(X-ray
1.73A
)
4A9H
(X-ray
2.05A
)
4A9I
(X-ray
2.25A
)
4A9J
(X-ray
1.90A
)
4A9M
(X-ray
2.06A
)
4A9N
(X-ray
1.85A
)
4A9O
(X-ray
1.78A
)
4AKN
(X-ray
1.82A
)
4ALG
(X-ray
1.60A
)
4ALH
(X-ray
1.78A
)
4J1P
(X-ray
1.08A
)
4MR5
(X-ray
1.63A
)
4MR6
(X-ray
1.67A
)
4QEU
(X-ray
1.50A
)
4QEV
(X-ray
1.80A
)
4QEW
(X-ray
1.70A
)
4UYF
(X-ray
1.60A
)
4UYG
(X-ray
2.50A
)
4UYH
(X-ray
1.73A
)
5BT5
(X-ray
1.40A
)
5DFB
(X-ray
1.40A
)
5DFC
(X-ray
1.50A
)
5DFD
(X-ray
1.50A
)
5DW1
(X-ray
1.55A
)
5EK9
(X-ray
2.08A
)
5HEL
(X-ray
1.45A
)
5HEM
(X-ray
1.65A
)
5HEN
(X-ray
1.79A
)
5HFQ
(X-ray
1.40A
)
5IBN
(X-ray
0.94A
)
5IG6
(X-ray
0.91A
)
5N2L
(X-ray
1.89A
)
5O38
(X-ray
1.20A
)
5O39
(X-ray
1.74A
)
5O3A
(X-ray
2.40A
)
5O3B
(X-ray
1.95A
)
5O3C
(X-ray
1.60A
)
5O3D
(X-ray
1.60A
)
5O3E
(X-ray
1.40A
)
5O3F
(X-ray
1.75A
)
5O3G
(X-ray
1.85A
)
5O3H
(X-ray
1.40A
)
5O3I
(X-ray
1.20A
)
5S9O
(X-ray
2.49A
)
5U5S
(NMR
-
)
5U6V
(X-ray
1.77A
)
5UEW
(X-ray
1.83A
)
5XHE
(X-ray
1.40A
)
5XHK
(X-ray
1.28A
)
6CUI
(NMR
-
)
6DB0
(X-ray
1.70A
)
6DBC
(X-ray
1.05A
)
6DDI
(X-ray
1.50A
)
6DDJ
(X-ray
1.05A
)
6E6J
(X-ray
2.44A
)
6FFE
(X-ray
1.76A
)
6FFF
(X-ray
1.67A
)
6FFG
(X-ray
1.59A
)
6I80
(X-ray
1.14A
)
6I81
(X-ray
1.74A
)
6JKE
(X-ray
1.50A
)
6K04
(X-ray
1.25A
)
6K05
(X-ray
1.94A
)
6MO7
(X-ray
1.85A
)
6MO8
(X-ray
1.80A
)
6MO9
(X-ray
1.80A
)
6MOA
(X-ray
1.27A
)
6ONY
(X-ray
1.98A
)
6SWO
(X-ray
1.60A
)
6SWP
(X-ray
1.60A
)
6TQ1
(X-ray
1.90A
)
6TQ2
(X-ray
2.26A
)
6U61
(X-ray
2.29A
)
6U71
(X-ray
1.47A
)
6U8H
(X-ray
2.07A
)
6ULQ
(X-ray
2.70A
)
6ULT
(X-ray
2.80A
)
6VIY
(X-ray
1.90A
)
6WWB
(X-ray
1.31A
)
6YTM
(X-ray
1.56A
)
6Z7F
(X-ray
1.60A
)
6Z8P
(X-ray
1.55A
)
6ZB0
(X-ray
1.61A
)
6ZB1
(X-ray
1.60A
)
6ZB2
(X-ray
2.28A
)
7DPN
(X-ray
1.80A
)
7DPO
(X-ray
2.30A
)
7ENV
(X-ray
2.45A
)
7ENZ
(X-ray
1.70A
)
7EO5
(X-ray
2.00A
)
7JX7
(X-ray
1.75A
)
7L6D
(X-ray
1.55A
)
7L9G
(X-ray
1.36A
)
7L9J
(X-ray
1.85A
)
7L9K
(X-ray
1.95A
)
7LAK
(X-ray
1.83A
)
7NPY
(X-ray
1.60A
)
7NPZ
(X-ray
1.28A
)
7NQ0
(X-ray
1.30A
)
7NQ1
(X-ray
1.60A
)
7NQ2
(X-ray
1.74A
)
7NQ3
(X-ray
1.60A
)
7NQ5
(X-ray
1.60A
)
7NQ7
(X-ray
1.70A
)
7NQ8
(X-ray
1.60A
)
7NQ9
(X-ray
1.60A
)
7NQI
(X-ray
1.60A
)
7NQJ
(X-ray
1.73A
)
7OE4
(X-ray
1.65A
)
7OE5
(X-ray
1.60A
)
7OE6
(X-ray
1.76A
)
7OE8
(X-ray
1.30A
)
7OE9
(X-ray
1.60A
)
7OEP
(X-ray
1.80A
)
7OER
(X-ray
1.60A
)
7OES
(X-ray
1.60A
)
7OET
(X-ray
1.41A
)
7OGY
(X-ray
1.60A
)
7Q5O
(X-ray
1.52A
)
7WLN
(X-ray
2.85A
)
7WMQ
(X-ray
2.37A
)
7WMU
(X-ray
1.73A
)
7WN5
(X-ray
1.70A
)
7WNA
(X-ray
2.60A
)
7WNI
(X-ray
3.12A
)
DBSNP
rs3918144
rs55669504
rs35952031
rs176250
rs35294809
rs3918143
rs1049369
rs34530779
rs55952113
Subcellular location [CC]
Nucleus {ECO:0000305}. Note=Detected on chromatin and nucleosomes.
Mouse PG classification
NA
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