Gene Information
Gene NameBRCC3
OrganismHomo sapiens (Human)
Gene Length316
Protein NamesLys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)
Target Namelys-63-specific deubiquitinase brcc36
Target TypeNA
Gene Age645 ( ENSG00000185515 )
Evolutionary StageEukaryota
AlphaFoldDBP46736
Gene CardBRCC3
Uniprot IDP46736
PfamPF18110; PF01398
In ASDno
Allosteric Predictionyes (0.405808212)
Ortholog in AnimalsAlpaca_ BRCC3 ( ortholog_one2one )
Mouse_ Brcc3 ( ortholog_one2many )
Mouse_ Gm5136 ( ortholog_one2many )
Pig_ BRCC3 ( ortholog_one2one )
Rat_ Gm5136 ( ortholog_one2many )
Rat_ Brcc3 ( ortholog_one2many )
Rabbit_ BRCC3 ( ortholog_one2one )
OhnologsNA
ParalogsPSMD14, COPS5, EIF3H
TissueNA
Tissue SpecificityHeart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors. {ECO:0000269|PubMed:16707425}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.010102(Rat);0.148891(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6H3C  (EM  3.90A  )  6R8F  (EM  3.80A  ) 
DBSNP rs28997578 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26344097}. Cytoplasm {ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000305|PubMed:26195665}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:20656690, PubMed:26344097). Interaction with ABRAXAS2 retains BRCC3 in the cytoplasm (PubMed:20656690). {ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:26344097}.
Mouse PG classificationNA
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