| Gene Information | |
|---|---|
| Gene Name | BRCA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 3418 |
| Protein Names | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000139618 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | BRCA2 |
| Uniprot ID | P51587 |
| Pfam | PF09169; PF09103; PF09104; PF00634; PF09121 |
| In ASD | no |
| Allosteric Prediction | yes (0.804792622) |
| Ortholog in Animals | Alpaca_ BRCA2 ( ortholog_one2one ) GuineaPig_ BRCA2 ( ortholog_one2one ) Macaque_ BRCA2 ( ortholog_one2one ) Mouse_ Brca2 ( ortholog_one2one ) Pig_ BRCA2 ( ortholog_one2one ) Rat_ Brca2 ( ortholog_one2one ) Rabbit_ BRCA2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | appendix, dura.mater, testis, zone.of.skin |
| Tissue Specificity | Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen. |
| Pharmacological Animal Models | 0.012244(Chimpanzee);0.012719(Mouse);0.002385(Rat);0.054545(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1N0W (X-ray 1.70A ) 3EU7 (X-ray 2.20A ) 6GY2 (X-ray 3.11A ) 6HQU (X-ray 1.97A ) 7BDX (X-ray 2.60A ) 7LDG (X-ray 2.56A ) |
| DBSNP | rs80358961 rs80359214 rs80359182 rs1555280339 rs4987046 rs397507595 rs80358463 rs397507615 rs28897701 rs80358507 rs80358567 rs80358603 rs80358805 rs397507822 rs397507873 rs80358897 rs766173 rs79483201 rs11571640 rs28897706 rs80359242 rs144848 rs876660828 rs80358423 rs56403624 rs28897708 rs28897709 rs80358451 rs80358457 rs28897710 rs1046984 rs80358469 rs587780646 rs80358479 rs80358487 rs757577670 rs397507620 rs11571653 rs80358526 rs2227943 rs28897716 rs11571656 rs28897717 rs2227944 rs1799944 rs1298550035 rs1799951 rs80358600 rs397507674 rs1060502384 rs41293485 rs70953664 rs28897727 rs80358687 rs397507729 rs56386506 rs28897728 rs28897729 rs2219594 rs398122784 rs80358703 rs28897731 rs56087561 rs397507770 rs80358755 rs370252983 rs80358765 rs11571657 rs397507795 rs4987048 rs4987117 rs79538375 rs28897737 rs28897739 rs1799954 rs56191579 rs80358862 rs34309943 rs397507838 rs55794205 rs55953736 rs397507847 rs80358876 rs11571659 rs11571660 rs397507875 rs28897742 rs55712212 rs1381512588 rs28897743 rs28897743 rs80358935 rs4986860 rs4986859 rs397507912 rs169547 rs80358965 rs80358968 rs11571707 rs55716624 rs56070345 rs80358979 rs28897744 rs80359013 rs80359014 rs80359022 rs80359027 rs80359031 rs28897746 rs80359055 rs80359062 rs41293513 rs41293511 rs28897749 rs80359065 rs80359071 rs80359078 rs28897751 rs80359082 rs11571746 rs80359104 rs11571747 rs4987047 rs28897754 rs11571769 rs59004709 rs28897755 rs45580035 rs80359176 rs80359187 rs80359198 rs41293521 rs28897758 rs80359204 rs56204128 rs28897759 rs80359228 rs11571831 rs55847618 rs80359245 rs770868371 rs80358388 rs56309455 rs1801426 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:24013206, ECO:0000269|PubMed:26833090, ECO:0000305|PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}. Note=Colocalizes with ERCC5/XPG to nuclear foci following DNA replication stress. {ECO:0000269|PubMed:26833090}. |
| Mouse PG classification | NA |
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