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Gene Information
Gene Name
BRAF
Organism
Homo sapiens (Human)
Gene Length
766
Protein Names
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)
Target Name
b-raf messenger rna
Target Type
Clinical trial target
Gene Age
645 ( ENSG00000157764 )
Evolutionary Stage
Eukaryota
AlphaFoldDB
P15056
Gene Card
BRAF
Uniprot ID
P15056
Pfam
PF00130; PF07714; PF02196
In ASD
yes
Allosteric Prediction
yes (1.546965219)
Ortholog in Animals
Alpaca_ BRAF ( ortholog_one2one )
Alpaca_ BRAF ( ortholog_one2many )
Dog_ BRAF ( ortholog_one2one )
GuineaPig_ BRAF ( ortholog_one2one )
Macaque_ BRAF ( ortholog_one2one )
Mouse_ Braf ( ortholog_one2one )
Pig_ BRAF ( ortholog_one2one )
Rat_ Braf ( ortholog_one2one )
Rabbit_ BRAF ( ortholog_one2one )
Ohnologs
ARAF, RAF1
Paralogs
LIMK2, RIPK1, LRRK2, TNNI3K, TESK2, KSR2, MAP3K10, RIPK2, MOS, MAP3K9, MLKL, MAP3K20, ARAF, TESK1, MAP3K13, ILK, MAP3K11, RAF1, MAP3K12, MAP3K21, LIMK1, KSR1, RIPK3
Tissue
NA
Tissue Specificity
Brain and testis.
Pharmacological Animal Models
NA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1UWH
(X-ray
2.95A
)
1UWJ
(X-ray
3.50A
)
2FB8
(X-ray
2.90A
)
2L05
(NMR
-
)
3C4C
(X-ray
2.57A
)
3D4Q
(X-ray
2.80A
)
3IDP
(X-ray
2.70A
)
3II5
(X-ray
2.79A
)
3NY5
(X-ray
1.99A
)
3OG7
(X-ray
2.45A
)
3PPJ
(X-ray
3.70A
)
3PPK
(X-ray
3.00A
)
3PRF
(X-ray
2.90A
)
3PRI
(X-ray
3.50A
)
3PSB
(X-ray
3.40A
)
3PSD
(X-ray
3.60A
)
3Q4C
(X-ray
3.20A
)
3Q96
(X-ray
3.10A
)
3SKC
(X-ray
3.20A
)
3TV4
(X-ray
3.40A
)
3TV6
(X-ray
3.30A
)
4CQE
(X-ray
2.30A
)
4DBN
(X-ray
3.15A
)
4E26
(X-ray
2.55A
)
4E4X
(X-ray
3.60A
)
4EHE
(X-ray
3.30A
)
4EHG
(X-ray
3.50A
)
4FC0
(X-ray
2.95A
)
4FK3
(X-ray
2.65A
)
4G9C
(X-ray
3.50A
)
4G9R
(X-ray
3.20A
)
4H58
(X-ray
3.10A
)
4JVG
(X-ray
3.09A
)
4KSP
(X-ray
2.93A
)
4KSQ
(X-ray
3.30A
)
4MBJ
(X-ray
3.60A
)
4MNE
(X-ray
2.85A
)
4MNF
(X-ray
2.80A
)
4PP7
(X-ray
3.40A
)
4R5Y
(X-ray
3.50A
)
4RZV
(X-ray
2.99A
)
4RZW
(X-ray
3.49A
)
4WO5
(X-ray
2.83A
)
4XV1
(X-ray
2.47A
)
4XV2
(X-ray
2.50A
)
4XV3
(X-ray
2.80A
)
4XV9
(X-ray
2.00A
)
4YHT
(X-ray
3.05A
)
5C9C
(X-ray
2.70A
)
5CSW
(X-ray
2.66A
)
5CSX
(X-ray
2.51A
)
5CT7
(X-ray
3.17A
)
5FD2
(X-ray
2.89A
)
5HI2
(X-ray
2.51A
)
5HID
(X-ray
2.50A
)
5HIE
(X-ray
3.00A
)
5ITA
(X-ray
1.95A
)
5J17
(NMR
-
)
5J18
(NMR
-
)
5J2R
(NMR
-
)
5JRQ
(X-ray
2.29A
)
5JSM
(X-ray
2.19A
)
5JT2
(X-ray
2.70A
)
5VAL
(X-ray
2.26A
)
5VAM
(X-ray
2.10A
)
5VR3
(X-ray
2.10A
)
5VYK
(X-ray
1.75A
)
6B8U
(X-ray
2.68A
)
6CAD
(X-ray
2.55A
)
6N0P
(X-ray
2.37A
)
6N0Q
(X-ray
2.04A
)
6NSQ
(X-ray
3.05A
)
6NYB
(EM
4.10A
)
6P3D
(X-ray
2.11A
)
6P7G
(X-ray
2.65A
)
6PP9
(X-ray
2.59A
)
6Q0J
(EM
4.90A
)
6Q0K
(EM
6.80A
)
6Q0T
(EM
5.70A
)
6U2G
(X-ray
2.89A
)
6U2H
(X-ray
2.50A
)
6UAN
(EM
3.90A
)
6UUO
(X-ray
3.29A
)
6V2U
(X-ray
3.78A
)
6V2W
(X-ray
3.12A
)
6V34
(X-ray
3.15A
)
6XAG
(X-ray
3.30A
)
6XFP
(X-ray
2.00A
)
6XLO
(X-ray
2.49A
)
7K0V
(X-ray
1.93A
)
7M0T
(X-ray
3.19A
)
7M0U
(X-ray
3.09A
)
7M0V
(X-ray
3.16A
)
7M0W
(X-ray
3.09A
)
7M0X
(X-ray
2.47A
)
7M0Y
(X-ray
3.45A
)
7M0Z
(X-ray
3.12A
)
7MFD
(EM
3.66A
)
7MFE
(EM
4.07A
)
7MFF
(EM
3.89A
)
7P3V
(X-ray
2.37A
)
DBSNP
rs387906660
rs387906661
rs387906660
rs397507465
rs397507466
rs180177034
rs180177035
rs397507470
rs34776339
rs180177032
rs180177033
rs121913348
rs121913348
rs121913351
rs121913351
rs121913351
rs869025606
rs397507473
rs121913355
rs121913355
rs121913357
rs121913355
rs180177036
rs180177037
rs397507476
rs180177039
rs180177038
rs869025340
rs606231228
rs180177040
rs121913370
rs121913340
rs121913338
rs121913341
rs121913361
rs397507483
rs121913366
rs121913369
rs121913375
rs121913377
rs113488022
rs121913364
rs121913364
rs180177042
rs397507486
Subcellular location [CC]
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19710016}. Cell membrane {ECO:0000269|PubMed:19710016}. Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. {ECO:0000250}.
Mouse PG classification
NA
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