| Gene Information | |
|---|---|
| Gene Name | LEO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 666 |
| Protein Names | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000166477 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WVC0 |
| Gene Card | LEO1 |
| Uniprot ID | Q8WVC0 |
| Pfam | PF04004 |
| In ASD | no |
| Allosteric Prediction | no (-0.11374167) |
| Ortholog in Animals | Alpaca_ LEO1 ( ortholog_one2one ) Dog_ LEO1 ( ortholog_one2one ) GuineaPig_ LEO1 ( ortholog_one2one ) Macaque_ LEO1 ( ortholog_one2one ) Mouse_ Leo1 ( ortholog_one2one ) Pig_ LEO1 ( ortholog_one2one ) Rat_ Leo1 ( ortholog_one2one ) Rabbit_ LEO1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver. {ECO:0000269|PubMed:15791002}. |
| Pharmacological Animal Models | 0.018120(Chimpanzee);0.135172(Mouse);0.017272(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4M6T (X-ray 2.50A ) 6GMH (EM 3.10A ) 6TED (EM 3.10A ) 7OOP (EM 2.90A ) 7OPC (EM 3.00A ) 7OPD (EM 3.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15791002}. |
| Mouse PG classification | NA |
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