| Gene Information | |
|---|---|
| Gene Name | GRAMD1C |
| Organism | Homo sapiens (Human) |
| Gene Length | 662 |
| Protein Names | Protein Aster-C (GRAM domain-containing protein 1C) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000178075 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IYS0 |
| Gene Card | GRAMD1C |
| Uniprot ID | Q8IYS0 |
| Pfam | PF02893; PF16016 |
| In ASD | no |
| Allosteric Prediction | no (-1.967375743) |
| Ortholog in Animals | Alpaca_ GRAMD1C ( ortholog_one2one ) Dog_ GRAMD1C ( ortholog_one2one ) GuineaPig_ GRAMD1C ( ortholog_one2one ) Macaque_ GRAMD1C ( ortholog_one2one ) Mouse_ Gramd1c ( ortholog_one2one ) Pig_ GRAMD1C ( ortholog_one2one ) Rat_ Gramd1c ( ortholog_one2one ) Rabbit_ GRAMD1C ( ortholog_one2one ) |
| Ohnologs | GRAMD1B, GRAMD1A |
| Paralogs | GRAMD1A, GRAMD2A, GRAMD1B, GRAMD2B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.027365(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6GN5 (X-ray 1.41A ) |
| DBSNP | rs17853381 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8CI52}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8CI52}; Single-pass membrane protein {ECO:0000255}. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS). {ECO:0000250|UniProtKB:Q8CI52}. |
| Mouse PG classification | NA |
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