| Gene Information | |
|---|---|
| Gene Name | BPI |
| Organism | Homo sapiens (Human) |
| Gene Length | 487 |
| Protein Names | Bactericidal permeability-increasing protein (BPI) (CAP 57) |
| Target Name | protein bactericidal permeability-increasing |
| Target Type | Clinical trial target |
| Gene Age | 424 ( ENSG00000101425 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P17213 |
| Gene Card | BPI |
| Uniprot ID | P17213 |
| Pfam | PF01273; PF02886 |
| In ASD | no |
| Allosteric Prediction | yes (0.247839293) |
| Ortholog in Animals | Alpaca_ BPI ( ortholog_one2one ) Dog_ BPI ( ortholog_one2one ) Macaque_ BPI ( ortholog_one2one ) Mouse_ Bpi ( ortholog_one2one ) Pig_ BPI ( ortholog_one2one ) Rat_ Bpi ( ortholog_one2one ) Rabbit_ BPI ( ortholog_one2one ) |
| Ohnologs | BPIFC |
| Paralogs | LBP, BPIFC, PLTP, CETP, BPIFB2, BPIFB6, BPIFB4, BPIFB3, BPIFA2, BPIFA1, BPIFA3, BPIFB1 |
| Tissue | bone.marrow |
| Tissue Specificity | Restricted to cells of the myeloid series. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BP1 (X-ray 2.40A ) 1EWF (X-ray 1.70A ) |
| DBSNP | rs5743497 rs5743498 rs1341023 rs5743500 rs5743506 rs5743509 rs4358188 rs5741804 rs5743524 rs5741809 rs5743542 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:8812832}. Cytoplasmic granule membrane {ECO:0000269|PubMed:2722846}. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000269|PubMed:2722846}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |