| Gene Information | |
|---|---|
| Gene Name | VRK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 508 |
| Protein Names | Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000028116 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q86Y07 |
| Gene Card | VRK2 |
| Uniprot ID | Q86Y07 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.041324519) |
| Ortholog in Animals | Alpaca_ VRK2 ( ortholog_one2one ) Dog_ VRK2 ( ortholog_one2one ) GuineaPig_ VRK2 ( ortholog_one2one ) Macaque_ VRK2 ( ortholog_one2one ) Mouse_ Vrk2 ( ortholog_one2one ) Pig_ VRK2 ( ortholog_one2one ) Rat_ Vrk2 ( ortholog_one2one ) Rabbit_ VRK2 ( ortholog_one2one ) |
| Ohnologs | VRK1, VRK3 |
| Paralogs | CSNK1G3, TTBK2, VRK3, CSNK1A1L, VRK1, CSNK1G1, CSNK1A1, CDC7, CSNK1G2, CSNK1E, CSNK1D, TTBK1 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis. {ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:20679487, ECO:0000269|PubMed:9344656}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2V62 (X-ray 1.70A ) 5UU1 (X-ray 2.00A ) 6NCG (X-ray 2.45A ) |
| DBSNP | rs34130684 rs35966666 rs1051061 rs36081172 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16704422}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16704422}; Single-pass type IV membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:16704422}; Single-pass type IV membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q8BN21}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16704422}. Nucleus {ECO:0000269|PubMed:16704422}. |
| Mouse PG classification | NA |
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