| Gene Information | |
|---|---|
| Gene Name | P4HA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 544 |
| Protein Names | Prolyl 4-hydroxylase subunit alpha-3 (4-PH alpha-3) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000149380 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7Z4N8 |
| Gene Card | P4HA3 |
| Uniprot ID | Q7Z4N8 |
| Pfam | PF13640; PF08336 |
| In ASD | no |
| Allosteric Prediction | no (-0.985050701) |
| Ortholog in Animals | Alpaca_ P4HA3 ( ortholog_one2one ) Dog_ P4HA3 ( ortholog_one2one ) GuineaPig_ P4HA3 ( ortholog_one2one ) Macaque_ P4HA3 ( ortholog_one2one ) Mouse_ P4ha3 ( ortholog_one2one ) Pig_ P4HA3 ( ortholog_one2one ) Rat_ P4ha3 ( ortholog_one2one ) Rabbit_ P4HA3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | P4HA2, P4HTM, P4HA1 |
| Tissue | dura.mater, epididymis, penis, smooth.muscle |
| Tissue Specificity | Highly expressed in placenta, liver and fetal skin. Weakly expressed in fetal epiphyseal cartilage, fetal liver, fibroblast, lung and skeletal muscle. Expressed also in fibrous cap of carotid atherosclerotic lesions. {ECO:0000269|PubMed:12874193, ECO:0000269|PubMed:14500733}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2282488 |
| Subcellular location [CC] | Endoplasmic reticulum lumen {ECO:0000305}. |
| Mouse PG classification | NA |
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