Gene Information
Gene NameBOK
OrganismHomo sapiens (Human)
Gene Length212
Protein NamesBcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000176720 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9UMX3
Gene CardBOK
Uniprot IDQ9UMX3
PfamPF00452
In ASDno
Allosteric Predictionno (-0.948338055)
Ortholog in AnimalsAlpaca_ BOK ( ortholog_one2one )
GuineaPig_ BOK ( ortholog_one2one )
Macaque_ BOK ( ortholog_one2one )
Mouse_ Bok ( ortholog_one2one )
Pig_ BOK ( ortholog_one2one )
Rat_ Bok ( ortholog_one2one )
OhnologsNA
ParalogsBAX, BCL2L10, MCL1, BCL2A1, BAK1, BCL2L1, BCL2L2, BCL2
TissueNA
Tissue SpecificityExpressed mainly in oocytes;
weak expression in granulosa cells of the developing follicles. In adult human ovaries, expressed in granulosa cells at all follicular stages, but expression in primordial/primary follicles granulosa cell is stronger than in secondary and antral follicles. {ECO:0000269|PubMed:20673843}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6CKV  (NMR  -  ) 
DBSNP NA 
Subcellular location [CC][Isoform 1]: Mitochondrion membrane {ECO:0000250|UniProtKB:O35425};
Single-pass membrane protein {ECO:0000250|UniProtKB:O35425}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27076518};
Single-pass membrane protein {ECO:0000250|UniProtKB:O35425}. Mitochondrion inner membrane {ECO:0000269|PubMed:24113155}. Cytoplasm {ECO:0000269|PubMed:15868100, ECO:0000269|PubMed:16302269, ECO:0000269|PubMed:19942931, ECO:0000269|PubMed:20673843, ECO:0000269|PubMed:24113155}. Nucleus {ECO:0000269|PubMed:16302269, ECO:0000269|PubMed:19942931, ECO:0000269|PubMed:20673843}. Mitochondrion {ECO:0000269|PubMed:15102863, ECO:0000269|PubMed:15868100, ECO:0000269|PubMed:19942931, ECO:0000269|PubMed:27076518}. Endoplasmic reticulum {ECO:0000269|PubMed:16302269}. Mitochondrion outer membrane {ECO:0000269|PubMed:27076518}. Early endosome membrane {ECO:0000250|UniProtKB:O35425}. Recycling endosome membrane {ECO:0000250|UniProtKB:O35425}. Nucleus outer membrane {ECO:0000250|UniProtKB:O35425}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:O35425}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:O35425}. Membrane {ECO:0000269|PubMed:19942931}. Note=Nuclear and cytoplasmic compartments in the early stages of apoptosis and during apoptosis it associates with mitochondria (PubMed:19942931). In healthy cells, associates loosely with the membrane in a hit-and-run mode. The insertion and accumulation on membranes is enhanced through the activity of death signals, resulting in the integration of the membrane-bound protein into the membrane (PubMed:15868100). The transmembrane domain controls subcellular localization;
constitutes a tail-anchor. Localizes in early and late endosome upon blocking of apoptosis. Must localize to the mitochondria to induce mitochondrial outer membrane permeabilization and apoptosis (By similarity). {ECO:0000250|UniProtKB:O35425, ECO:0000269|PubMed:15868100, ECO:0000269|PubMed:19942931}.;
[Isoform 2]: Membrane {ECO:0000269|PubMed:19942931}. Cytoplasm {ECO:0000269|PubMed:19942931}.
Mouse PG classificationNA
click here to return to the previous page